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13 Cards in this Set

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What is the mechanism of action of cyclosporine A
Complexes with cyclophilin to inhibit calcineurin thereby decreasing IL-2, which is the main inducer for activation of T lymphocytes
What are the main therapeutic indications of cyclosporine A
Prevention of organ rejection in heart, kidney, and liver transplants
What are the adverse effects of cyclosporine A
Nephrotoxicity
Hepatotoxicity
CMV infections
Hypertension
Hyperkalemia
Hirsutism
Glucose intolerance
Gingival hyperplasia
Tremor
Upper respiratory infections
Anemia
Leukopenia
Thrombocytopenia
None
Name three medications that can cause gingival hyperplasia
Cyclosporin; Phenytoin; Nifedipine
What major hepatic enzyme metabolizes cyclosporine A
CYP 3A4
Cyclosporine A becomes more effective as an immunosuppressant when combined with what class of drugs
Glucocorticoids
FK506 is also known as what
Tacrolimus
What are the main therapeutic indications of tacrolimus
Prevention of organ rejection in liver and kidney transplants
What is the mechanism of action of tacrolimus
Inhibits calcineurin by binding to FK binding protein (FKBP) rather than cyclophilin
What are the adverse effects of tacrolimus
Nephrotoxicity; neurotoxicity; hypertension; headache; tremor; rash; hyperglycemia; hyperkalemia; anemia; leukocytosis; thrombocytopenia
Which murine monoclonal antibody interferes with T-lymphocyte function by binding to CD3 glycoprotein
Muromonab-CD3 (OKT3)
Which immunosuppressant is a derivative of 6-mercaptopurine, antagonizes purine metabolism, and is cytotoxic to lymphocytes
Azathioprine
Which immunosuppressant inhibits inosine monophosphate dehydrogenase thereby inhibiting de novo guanosine nucleotide synthesis
Mycophenolate mofetil