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68 Cards in this Set
- Front
- Back
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Which of the following actions is caused by diazepam?
A. Increased affinity of the beta subunit of GABA-A receptor for agonists. B. Decreased opening frequency of GABA-controlled chloride ion channels. C. Decreased activity of voltage-sensitive calcium channels. D. Decreased activity of NMDA receptors. E. All of the above |
A. Increased affinity of the beta subunit of GABA-A receptor for agonists.
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Which of the following drugs can decrease the effects of diazepam on GABA-A receptor function?
A. Bicuculline B. Chronic exposure to ethanol C. Flumazenil D. Picrotoxin E. All of the above |
E. All of the above
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Which of the following agents would be best indicated for the prevention of alcohol-withdrawal-induced seizures?
A. Diazepam B. Midazolam C. Odansetron D. Triazolam E. All of the above |
A. Diazepam
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Which of the following agents would be best indicated for the treatment of insomnia with the least risk of residual side effects?
A. Midazolam B. Eszopiclone C. Flurazepam D. Oxazepam E. None of the above |
B. Eszopiclone
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Which of the following agents would be best indicated for use in combination with general anesthetics so as to lower the dose of the anesthetic?
A. Odansetron B. Diazepam C. Midazolam D. Alprazolam E. All of the above |
C. Midazolam
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Which of the following agents will be affected by induction of the activity of CYP3A4?
A. Haloperidol B. Cortisol C. Morphine D. Phenytoin E. All of the above |
E. All of the above
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Which of the following disorders responds favorably to therapy with buspirone, usually in combination with paroxetine or another SSRI?
A. Panic disorder B. Social phobias C. Post-traumatic stress disorder D. Obsessive Compulsive disorder E. None of the above |
E. None of the above
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Which of the following drugs does not inhibit glutamate receptor activation?
A. Ethanol B. Chlordiazepoxide C. Dextromethorphan D. Ketamine E. All of the above |
B. Chlordiazepoxide
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Which of the following statements is true about buspirone?
A. Its anxiolytic actions wear off after a couple of weeks. B. It will act as an agonist at 5HT-1A postsynaptic receptors to decrease signal transduction if there is a lot of endogenous serotonin around. C. It will act as an antagonist at 5HT-1A autoreceptors to decrease neuronal firing if there is a lot of endogenous serotonin around. D. It will act as an agonist at 5HT-1A autoreceptors to decrease neuronal firing if there is very little endogenous serotonin around. E. None of the above |
D. It will act as an agonist at 5HT-1A autoreceptors to decrease neuronal firing if there is very little endogenous serotonin around.
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Repeated use of which of the following agents is least likely to affect GABA-A receptor subunit composition when used repeatedly?
A. Ethanol B. Eszopiclone C. Pentobarbital D. Diazepam E. All of the above |
B. Eszopiclone
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Which of the following drugs causes less inhibition of REM sleep?
A. Triazolam B. Ethanol C. Diazepam D. Phenobarbital E. None of the above |
E. None of the above
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How would switching from a short‑acting benzodiazepine to a longer acting benzodiazepine affect the severity of residual daytime drowsiness caused by this treatment? Increase, decrease, no change
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Increase
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True/False
Diazepam increases the activity of GABA-A receptors |
True
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True/False
Diazepam exhibits pharmacokinetic tolerance with repeated daily use? |
False
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How would switching from a short‑acting benzodiazepine to a longer acting benzodiazepine affect the severity of benzodiazepine withdrawal symptoms? increase, decrease, no change
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Decrease
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True/False
Diazepam decreases the activity of glutamate receptors |
False
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True/False
Diazepam exhibits pharmacodynamic tolerance with repeated daily use |
True
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How would switching from a longer acting benzodiazepine to a short‑acting benzodiazepine affect the severity of residual daytime drowsiness caused by this treatment?
Increase Decrease No change |
Decrease
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How would switching from a short‑acting benzodiazepine to a longer acting benzodiazepine affect the severity of residual daytime drowsiness caused by this treatment?
Increase Decrease No change |
Increase
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Which of the following actions is caused by diazepam?
a. Increased affinity of the beta subunit of GABA-A receptor for agonists. b. Increased opening frequency of GABA-controlled chloride ion channels. c. Decreased activity of voltage-sensitive calcium channels. d. A and B are both true e. All of the above |
d. A and B are both true
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Which of the following drugs can decrease the effects of midazolam on GABA-A receptor function but will not affect the actions of ethanol on GABA-A receptor function?
a. Bicuculline b. Chronic exposure to midazolam c. Picrotoxin d. Flumazenil e. All of the above |
d. Flumazenil
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Which of the following agents would be best indicated for the treatment of anxiety with the least risk of sedative side effects?
a. Alprazolam b. Flurazepam c. Prazepam d. Diazepam e. All of the above |
a. Alprazolam
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Which of the following agents would be best indicated for the treatment of insomnia with the least risk of residual sedative side effects?
a. Ramelteon b. Triazelam c. Eszopiclone d. Zolpidem e. All of the above |
e. All of the above
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Which of the following agents would be best indicated for use in treating certain epilepsies with less sedative side effects?
a. Odansetron b. Diazepam c. Midazolam d. Clonazepam e. All of the above |
d. Clonazepam
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Which of the following disorders responds favorably to therapy with buspirone in combination with venlafaxine?
a. Panic disorder b. Social phobias c. Mixed anxiety/depression disorder d. Generalized anxiety disorder e. All of the above |
c. Mixed anxiety/depression disorder
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Which of the following statements is true about buspirone?
a. Its takes a few weeks of dosing for maximal therapeutic benefit. b. It will act as an antagonist at 5HT-1A postsynaptic receptors to decrease signal transduction if there is a lot of endogenous serotonin around. c. It probably causes complex alterations in both pre- and post-synaptic serotonin receptors after repeated use. d. It will act as an agonist at 5HT-1A autoreceptors to decrease neuronal firing if there is very little endogenous serotonin around. e. All of the above |
e. All of the above
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Repeated use of which of the following agents is most likely to affect GABA-A receptor subunit composition when used repeatedly?
a. Ethanol b. Diazepam c. Pentobarbital d. Alprazolam e. All of the above |
e. All of the above
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Which of the following drugs block or reverse dopamine transporters?
a. Sertraline b. Buspirone c. Venlafaxine d. Bupropion e. All of the above |
d. Bupropion
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Which of the following drugs causes less inhibition of REM sleep?
a. Phenobarbital b. Triazolam c. Diazepam d. Eszopiclone e. All of the above |
d. Eszopiclone
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Which of the following actions is caused by diazepam?
A. Increased affinity of the alpha subunit of GABA-A receptor for agonists. B. Increased opening frequency of GABA-controlled chloride ion channels. C. Decreased activity of voltage-sensitive calcium channels. D. Decreased activity of AMPA receptors. E. All of the above |
B. Increased opening frequency of GABA-controlled chloride ion channels.
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Which of the following drugs can decrease the effects of zolpidem on GABA-A receptor function but will not affect the actions of ethanol on GABA-A receptor function?
A. Bicuculline B. Chronic exposure to pentobarbital C. Flumazenil D. Picrotoxin E. All of the above |
C. Flumazenil
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Which of the following agents would be best indicated for the treatment of anxiety with the least risk of sedative side effects?
A. Midazolam B. Eszopiclone C. Flurazepam D. Oxazepam E. All of the above |
D. Oxazepam
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Which of the following agents would be best indicated for the treatment of insomnia with the least risk of residual side effects?
A. Zolpidem B. Zaleplon C. Eszopiclone D. Ramelteon E. All of the above |
E. All of the above
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Which of the following agents would be best indicated for use in combination with general anesthetics?
A. Odansetron B. Midazolam C. Clonazepam D. Alprazolam E. All of the above |
B. Midazolam
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Which of the following disorders responds favorably to therapy with buspirone, usually in combination with another agent?
A. Panic disorder B. Social phobias C. Post-traumatic stress disorder D. Generalized anxiety disorder E. All of the above |
D. Generalized anxiety disorder
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Which of the following statements is true about buspirone?
A. Its anxiolytic actions wear off after a couple of weeks. B. It will act as an antagonist at 5HT-1A postsynaptic receptors to decrease signal transduction if there is a lot of endogenous serotonin around. C. It will act as an antagonist at 5HT-1A autoreceptors to decrease neuronal firing if there is a lot of endogenous serotonin around. D. It will act as an agonist at 5HT-1A autoreceptors to increase neuronal firing if there is very little endogenous serotonin around. E. All of the above |
B. It will act as an antagonist at 5HT-1A postsynaptic receptors to decrease signal transduction if there is a lot of endogenous serotonin around.
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Repeated use of which of the following agents is least likely to affect GABA- A receptor subunit composition when used repeatedly?
A. Ethanol B. Diazepam C. Pentobarbital D. Bretazenil E. All of the above |
D. Bretazenil
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Which of the following drugs block or reverse dopamine transporters?
A. Bupropion B. Buspirone C. Ethanol D. Sertraline E. All of the above |
A. Bupropion
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Which of the following drugs causes less inhibition of REM sleep?
A. Eszopiclone B. Ethanol C. Diazepam D. Phenobarbital E. All of the above |
A. Eszopiclone
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Which of the following actions is caused by diazepam?
A. Increased affinity of the GABA-A receptor for agonists. B. Decreased activity of NMDA receptors. C. Increased opening frequency of GABA-controlled chloride ion channels. D. Decreased activity of voltage-sensitive calcium channels. E. All of the above are correct F. Only A and C are true. |
F. Only A and C are true.
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Which of the following actions is caused by phenobarbital?
A. Increased affinity of the GABA-A receptor for agonists. B. Decreased activity of NMDA receptors. C. Increased opening time of GABA-controlled chloride ion channels. D. Decreased activity of voltage-sensitive calcium channels. E. All of the above are correct F. Only A and C are true. |
E. All of the above are correct
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Which of the following drugs can decrease the effects of zaleplon on GABA- A receptor function but will not affect the actions of phenobarbital on GABA-A receptor function?
A. Flumazenil. B. Picrotoxin C. Chronic exposure to ethanol. D. Bicuculline E. All of the above are correct F. Only A and C are true. |
A. Flumazenil.
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Which of the following agents would be best indicated for the treatment of anxiety with the least chance of causing residual side effects?
A. Alprazolam. B. Zolpidem C. Chlorazepate D. Triazolam E. All of the above are correct F. Only A and C are true. |
A. Alprazolam.
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Which of the following agents would be best indicated for the treatment of insomnia with the least risk of residual side effects?
A. Zolpidem. B. Midazolam C. Eszopiclone D. Diazepam E. All of the above are correct F. Only A and C are true. |
F. Only A and C are true.
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Which of the following agents would be best indicated for the prevention of alcohol-withdrawal-induced seizures?
A. Odansetron. B. Midazolam C. Diazepam D. Alprazolam E. All of the above are correct F. Only A and C are true. |
C. Diazepam
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Which of the following disorders responds better to combined therapy of gepirone with paroxetine compared to separate use of paroxetine or gepirone alone?
A. Acute anxiety disorder. B. Panic disorder C. Mixed anxiety/depressive disorder D. Post-traumatic stress disorder E. All of the above are correct F. Only A and C are true. |
C. Mixed anxiety/depressive disorder
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Which of the following statements is true about buspirone?
A. It will act as an agonist at 5HT-1A autoreceptors to decrease neuronal firing if there is very little endogenous serotonin around. B. It will act as an antagonist at 5HT-1A autoreceptors to increase neuronal firing if there is a lot of endogenous serotonin around. C. It will act as an agonist at 5HT-1A postsynaptic receptors to increase signal transduction if there is very little endogenous serotonin around. D. It will act as an antagonist at 5HT-1A postsynaptic receptors to decrease signal transduction if there is a lot of endogenous serotonin around. E. All of the above are correct F. Only A and C are true. |
E. All of the above are correct
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Which of the following is true?
A. Diazepam enhances GABA activation of GABA-A receptors comprised of any alpha, beta and gamma subunits. B. Diazepam specifically increases the open time of the ion channel in the GABA-A receptor. C. Phenobarbital specifically increases the opening frequency of the ion channel in the GABA-A receptor. D. All of the above E. Only A and C are true. |
A. Diazepam enhances GABA activation of GABA-A receptors comprised of any alpha, beta and gamma subunits.
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Which of the following drugs will completely block the effect of diazepam on GABA-A receptor function without altering the effect of phenobarbital on GABA-A receptor function?
A. Bicuculline B. Picrotoxin C. Flumazenil D. All of the above E. Only A and C are true. |
C. Flumazenil
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Which of the following drugs will completely block the effect of diazepam on GABA-A receptor function and partially block the effect of phenobarbital on GABA-A receptor function?
A. Bicuculline B. Picrotoxin C. Flumazenil D. All of the above E. Only A and C are true. |
A. Bicuculline
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Which of the following drugs will completely block the effects of both diazepam and phenobarbital on GABA-A receptor function?
A. Bicuculline B. Picrotoxin C. Flumazenil D. All of the above E. Only A and C are true. |
B. Picrotoxin
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Which of the following drugs binds only to the beta subunit of the GABA-A receptor?
A. Bicuculline B. Picrotoxin C. Flumazenil D. All of the above E. Only A and C are true. |
A. Bicuculline
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Which of the following drugs binds only to the alpha subunit of the GABA-A receptor?
A. Bicuculline B. Picrotoxin C. Flumazenil D. All of the above E. Only A and C are true. |
C. Flumazenil
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Which of the following statements are true when comparing the anxiolytic effects of six weeks of daily therapy with buspirone vs. a similar duration of treatment with low doses of alprazolam?
A. Synergistic effects on anxiety are apparent when both agents are taken together. B. There is sensitization to the effects of buspirone. C. There is a greater risk of rebound anxiety upon withdrawal from chronic alprazolam. D. Alprazolam would exhibit significantly greater development of tolerance than buspirone. E. All of the above F. Only A, B and C are true. |
F. Only A, B and C are true.
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Buspirone plus sertraline is most effective in treating which of the following anxiety disorders
A. Obsessive compulsive disorder B. Panic disorder C. Generalized anxiety disorder D. Anxiety associated with public speaking E. Post traumatic stress disorder F. Mixed anxiety/depressive disorder. |
F. Mixed anxiety/depressive disorder.
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Withdrawal from this sedative agent is more severe than withdrawal from lorazepam.
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
I. Triazelam
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This anxiolytic drug has few sedative effects because it may only bind to alpha-5 subunits.
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
C. Imidazenil
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This sedative agent that binds to GABA-A receptors but causes the least disruption in REM sleep
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
F. Zopiclone
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The benzodiazepine of choice for inducing rapid but short-lasting preanesthesia
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
G. Midazolam
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A patient that has been taking oxazepam on a daily basis might experience more serious daytime drowsiness if switched to this drug
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
B. Diazepam
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This anticonvulsant has fewer sedative side effects because it is a partial benzodiazepine agonist.
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
D. Clonazepam
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This anticonvulsant has fewer sedative side effects because it only binds to receptors with beta-2 subunits.
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
H. Loreclezole
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Blood levels of an active metabolite of this agent will build up if the drug is taken on a daily basis
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
B. Diazepam
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The longest acting full benzodiazepine agonist on this list
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
B. Diazepam
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Binds only to GABA-A receptors with an alpha-1 subunit present.
A. Alprazolam B. Diazepam C. Imidazenil D. Clonazepam E. Gamma-hydroxybutyrate F. Zopiclone G. Midazolam H. Loreclezole I. Triazelam |
F. Zopiclone
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Diazepam
A. Directly stimulate dopamine neuronal firing B. Increase GABA inhibition of dopamine neuronal firing C. No effect on mesolimbic dopamine activity when used alone D. Mimic increased dopamine activity by blocking dopamine transporters E. Increases dopamine neuronal transmission but mechanism unknown. F. Decrease GABA inhibition of dopamine neuronal firing G. Directly inhibit dopamine neuronal firing |
C. No effect on mesolimbic dopamine activity when used alone
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Lorazepam
A. Directly stimulate dopamine neuronal firing B. Increase GABA inhibition of dopamine neuronal firing C. No effect on mesolimbic dopamine activity when used alone D. Mimic increased dopamine activity by blocking dopamine transporters E. Increases dopamine neuronal transmission but mechanism unknown. F. Decrease GABA inhibition of dopamine neuronal firing G. Directly inhibit dopamine neuronal firing |
C. No effect on mesolimbic dopamine activity when used alone
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Buspirone
A. Directly stimulate dopamine neuronal firing B. Increase GABA inhibition of dopamine neuronal firing C. No effect on mesolimbic dopamine activity when used alone D. Mimic increased dopamine activity by blocking dopamine transporters E. Increases dopamine neuronal transmission but mechanism unknown. F. Decrease GABA inhibition of dopamine neuronal firing G. Directly inhibit dopamine neuronal firing |
C. No effect on mesolimbic dopamine activity when used alone
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