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32 Cards in this Set
- Front
- Back
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what s the function of H2 receptors in parietal cells?
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increase inctracellular cGMP (thus a Gs receptor)
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stimulation of H1 receptors is directly related to (3)
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allergic reactions and anaphylaxis
smooth muscle contraction in bronchioles cardiovascular vasodilation and release of NO |
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anytime you release NO you stimulate...
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formation of cGMP and guanalyte cyclase
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what is local edema in allergies caused by?
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capillary endothelial cells releasing EDRF and contracting
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what is histamine released in response to?
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IgE mediated reactions
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what two lungs have the greatest concentration of histamine?
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lungs and skin
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what is the drug of choice for anaphylaxis?
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epinephrinie
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first generation antihistamines are indicated in
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patients who require sedation
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what are the major side effects of first generation antihistamines?
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strong sedative effects
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what occurs due to the low specificity of first generation antihistamines with muscarinic, cholinergic, and adrenergic receptors?
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potentiation of CNS depressants and alcohol
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what is cyclizine?
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first generation antihistamine
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what is diphenhydramine?
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first generation antihistamine
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what is meclizine?
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first generation antihistamine
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what is promethazine?
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first generation antihistamine
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what is azelastine?
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first generation antihistamine
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what is cyclizine indicated for?
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motion sickness
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what is diphenhydramine indicated for?
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benadryl
can also be used in parkinsons to stop the shakes |
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what is meclizine indicated for?
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motion sickness
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what is promethazine indicated for?
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best used for post-operative pain due to significant sedation and hangover effects
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what is azelasine indicated for?
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intranasal spray
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what differentiates second from first generation antihistamines?
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far less lipid soluble than first generation so it is almost free of sedation and autonomic effects
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where are second generation antihistamines metabolized?
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liver
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what is fexofenadine?
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second generation antihistamine
(allegra) |
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what is loratadine?
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second generation antihistamine
(claratin) |
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what is cetirizine?
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second generation antihistamine
(zyrtec) |
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what is a side effect of cetirizine?
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may also cause sedation
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what is cimetidine?
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H2 antagonist
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What is ranitidine?
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H2 antagonist
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what is famotitine?
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H2 antagonist
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what is nizatidine?
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H2 antagonist
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what H2 antagonist has anti-androgen effects and decreases hepatic blood flow?
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cimetidine
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what H2 antagonist is a potent cyp450 inhibitor?
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cimetidine
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