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22 Cards in this Set
- Front
- Back
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at what level is it considered hyperuricemia?
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7mg/dL
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what are the top 2 NSAIDs for hyperuricemia?
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indomethacin
ibuprofen |
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what drug do textbooks recommend if patients with gout do not respond to NSAIDs?
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colchicine
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how does colchicine work? (3)
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arrests cell division, cell mobility, and releases chemotactic factors
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what are the side effects of colchicine?
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GI upset and bone marrow suppression
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what side effect limits the dosage of colchicine?
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GI effects
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what side effect limits the duration of colchicine usage?
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bone marrow suppression
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what is the best dose for colchicine?
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one single dose
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how is colchicine supposed to be administered?
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one dose every hour until symptoms abate or GI distress occurs
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what type of drug should be given in gouty patient who are not responding to NSAIDs or colchicine?
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corticosteroids
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what is triamcinolone?
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a corticosteroid
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what is the risk factor of triamcinolone?
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sepsis and infection
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when should allopurinol be used?
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when the patient has stabilized and had gone on a diet and remains hyperuricemic
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what is the MOA of allopurinol?
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competitively inhibits xanthine oxidase, the enzyme that catalyzes the final step in uric acid formation
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what do you give if a patient wants to go on vacation and eat shellfsh?
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allopurinol prophylactically
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where is allopurinol metabolized?
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the liver
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how is allopurinol excreted?
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slowly through the urine
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what do you give prophylactically to children about to undergo chemo?
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allopurinol
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what does probenicid do?
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blocks the tubular reabsorption of uric acid and is used to lower serum levels in chronic gout
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what is probenicid indicated for?
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urate under-excreters
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what is the risk with probenicid and how can it be minimized?
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renal lithiasis
patients should remain hydrated |
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who is probenicid contraindicated in?
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patients with a GFR < 60 (renal dysfunction)
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