Pharmacology 18 Drugs Relieving Anxiety And Promoting Sleep

Front 1

(P) LORAZEPAM

Back 1

RELIEVING ANXIETY & PROMOTES SLEEP & seizure disorders

4:
Anxiety & Insomnia

MECH:
increases inhibitory effects of GABA - SHORT duration of action = 2 - 3 doses/day

CONTRAS:
psychoses narrow-angle Glaucoma
<6 yrs

ADVERSES:
confusion/ ataxia/ drowsiness
bradycardia
hypOtension
PARADOXICAL RXs

**lasts longer in Asians**

*Preg cat D

*assess 4 suicidals*

* Taper dose down*

**NO alcohol / CNS depressents (avoids addictive CNS depression**

Front 2

BUSPIRONE

Back 2

4:
Short-term (~ 1yr) relief of Anxiety

MECH:
unkonwn - but likes serotonin receptors

**Optimum relief after 3-4 weeks of Tx**

Front 3

HYDROXIZINE

Back 3

Misc. anti-ANXIETY drug

- CNS depressent in subcortical areas

- rapid acting calm

- doesn't hit your alertness

- sometimes coadministered with Narcotic to min. Nausea

**NOT COMMON**

Front 4

ESZOPICLONE

Back 4

NON-BENZODIAZEPINE HYPNOTIC

works in GABA - benzodiazepine synapses

- only insomnia drug approved for LONG TERM USE (up to 6 months)

- rapid onset

SIDE Fx:
headA
prolonged drowsiness
bad taste

Front 5

ZOLPIDEM

Back 5

SHORT TERM INSOMNIA Tx (7-10 DAYS)

- rapid onset

- shares some pharm props w/ bezodiazepines (but not chem relatd)

- preserves ALL sleep stages - minor Fxs on REM

SIDES:
prolonged sleepiness
head A
dizziness