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14 Cards in this Set

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What forms of the aspirin are in aqueous solution?
Neutral and ionized forms of aspirin co-exist in aqueous solution
What type of base turns to solid in solution?
Weak base - BH+ <-> B(s) + H+(aq)
What happens when u ↑ the pH in weak acid drug?
The equation will sift to the right thus ↑ [A-] in the blood thus causing less neutral form of drug thus slowing movement of drug(ie asprin the the stomach thus ↓ transport of asprin from stomach to blood)
Pyrimethamine cation
Weak base -> neutral pyrimethamine + proton
What happens when u ↓ pH in weak acid drug?
The equation will shift to the left thus ↑ [HA] in the blood thus causing ↑ in neutral form of drug that ↑ movement of drug(ie asprin in stomach thus allows transport of asprin from stomach to blood)
What is the lipid soluble form for weak acid? Weak base?
NOTE NEUTRAL FORMS MOVE; Weak acid lipid soluble form = HA(solid), weak base lipid soluble form = B(solid)
What is the hendersen-hasslebach equation?
pH = pKa - log([acid]/[base])
What is the henderson-hasselbach equation for acids?
Log([HA]/[A-]) = pKa-pH
What is the henderson-hasselbach equation for bases?
Log ([BH+]/[B]) = pKa - pH
What is the side effect of first generation H1 blockers?
H1 blocker = blocks histamine (ie allergies) - side effect = sedation + drowsiness
What is the MOA of first generation H1 blocker?
The drug is evenly distributed in plasma and CNS thus causes sedation + drowsiness
What is the MOA of second generation H1 blocker?
The drug pH has it stay in the plasma ONLY thus dosent cause sedation + drowsiness
How does the body use pH differences to remove weak acid overdose(poisoning)
As u ↑ pH (more basic) the weak acid tends to be in the basic form thus stays in the urine ->not reabsorbed = ↑ [weak acid ionized form] in the urine -> able to excrete out the weak acid and lowers overall toxicity in plasma
How to prolong the half-life in body for weak base drug?
Weak base drug -> ionized in urine thus its moved into the urine (pH 4.5) -> turns to unionized form B b/c the pH is ↑ (↓ [H+]) thus its reabsorbed into the blood