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17 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Metformin
What is the class, MOA and branded name(s)? |
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Glucophage
Glucophage XL |
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What is the MOA of Sulfonylureas?
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Which class of drugs improve insulin secretion?
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-- Sulfonylureas
-- DPP-4 inhibitors -- Glinides |
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Which classes of drugs decrease hepatic glucose production?
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-- Metformin
-- DPP-4 inhibitors -- TZDs |
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Which class of drugs improve glucose uptake and utilization?
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-- Metformin
-- TZDs |
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Which drugs delay glucose absorption?
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-- Metformin
-- Alpha Glucosidase inhibitors |
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Name the first and second generation sulfonylureas
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Biuanide
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Generic: Metformin
Branded Glucophage Glucophage XL |
MOA-
--decrease hepatic glucose production --decrease intestinal absorption --improves insulin sensitivity |
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Sulfonylureas
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Branded
1st-- Chlorpropamide, tolbutamide 2nd -- glyburide, glipizide |
MOA--
insulin secretagogues-- lower blood glucose by stimulating insulin secretion from the beta-cells of the pancreas |
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Glinides
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Generic: Repaglinide, Nateglinide
Branded: Prandin Starlix |
MOA--
insulin secretagogues Produces a rapid short lived secretion of insulin |
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TZDs Thiazolidinediones
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Generic: Rosiglitazone Priglitazone
Branded: Avandia Actos |
MOA--
Insulin sensitizers. -- Improve hepatic sensitivity to insulin -- enhance cellular resonsiveness to insulin |
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Bile Acid Sequestrant
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Generic: Colesevelam
Branded: Welchol |
MOA--
unknown |
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Combination Products
Glucovance |
sulfonylurea + metformin
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TZD + Metformin
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Actoplus Met
AvandaMet |
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TZD + sulfonylurea
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Duetact
Avandaryl |
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DPP-4 inhibitor + metformin
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Januvia
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MOA of DPP-4 Inhibitors
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