Pharmacokinetics Test 3 Set 3

Front 1

Nonrestrictive CL drugs are...(2)

Back 1

1)HIGH EXTRACTION RATIO
2)FLOW DEPENDENT

Front 2

Restivctive CL drugs are...(2)

Back 2

1)FLOW INDEPENDENT
2)LOW EXTRACTION RATIO

Front 3

Hepatic extraction ratio effect when drug protein binding changes

Back 3

1)For NONrestictive drugs; NO change
2)For restictive drugs; extraction ratio will decr if fub decr and so on

Front 4

Hepatic blood CL effect when drug protein binding changes

Back 4

1)For NONrestictive drugs; NO change
2)For restictive drugs; hepatic blood CL will decr if fub decr and so on

Front 5

TOTAL CL effect when drug protein binding changes

Back 5

1)For NONrestictive drugs; NO change
2)For restictive drugs; total CL will decr if fub decr and so on

Front 6

Vd effect when drug protein binding changes

Back 6

incr fub = incr Vss and so on

Front 7

Half-life effect when drug protein binding changes

Back 7

incr fub = decr half-life and so on

Front 8

SS total drug [] effect when drug protein binding changes

Back 8

1)For NONrestictive drugs; NO change
2)For restictive drugs; ss[] will decr if fub decr and so on

Front 9

SS unbound free drug [] (Cuss) effect when drug protein binding changes

Back 9

1)For NONrestictive drugs; NO change
2)For restictive drugs; unbound ss[] will decr if fub decr and so on

Front 10

Bioavailability effect when drug protein binding changes

Back 10

1)For NONrestictive drugs; incr F = incr fub and so on
2)For restictive drugs; no change

Front 11

_____ drug is more likely to be polymorphic

Back 11

drug w/ a highly RESTRICTIVE CL

Front 12

Nonrestrictive CL drugs have... (4)

Back 12

1)high ER
2)high unbound intrinsic CL
3)high hepatic CL
4)ER > fub

Front 13

Restrictive CL drugs have...(4)

Back 13

1)low ER
2)low unbound intrinsic CL
3)low hepatic CL
4)ER =< fub