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13 Cards in this Set
- Front
- Back
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enteral
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oral
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parenteral
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by injection
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intrathecal
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into the subarachnoid space
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bioavailability
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fraction of the administered drug that reaches the systemic circulation
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volume of distribution Vd
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amount of drug in body/plasma drug concentration
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first pass metabolism
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all orally ingested drugs are first metabolized by the liver before entry into systemic circulation
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phase 1 reaction
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oxidation/reduction by P450 to make drug more soluble
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phase 2 reaction
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conjugation by P450 to make drug more soluble
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urinary/renal excretion
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drugs that have been made hydrophilic by P450
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biliary excretion
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lipophilic drugs solubulized in the bile and excreted as feces
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zero-order elimination
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elimination rate is not dependent on starting concentration
linear elimination |
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first-order elimination
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rate of elimination dependent on starting concentration
concentration decreases exponentially with time |
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half-life
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time required for drug plasma concentration to decrease by 50%
0.7xVd/CL |
