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11 Cards in this Set
- Front
- Back
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Abacavir |
HLA-B 5701 -If positive, do not use -Serious/fatal hypersensitivity reaction |
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Allopurinol |
HLA-B 5801 -If positive, do not use drug -Increased risk of SJS |
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Phenytoin |
HLA-B*1502 (all asian parents) -If positive, do not use -Association b/w SJS & TEN development if allele present |
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Carbamazepine |
HLA-B 1502 (Test all Asians) -If positive, do not use -Serious skin reactions (SJS/TEN) |
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Cetuximab |
KRAS -If positive for mutation, do not use (use if wild-type) -Not effective in pt's with mutation |
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Trastuzumab |
HER2 Protein -If negative, do not use (tumor must be +2, +3, NOT +1 OR NEGATIVE) -Overexpression required for use |
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Clopidogrel |
Cyp450 2c19 Genotype -Consider alt. tx if poor metabolizer (*2 *3 allelle) -2C19*1 is fully functional (can convert drug to active metabolite) |
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Warfarin |
Cyp450 2C9*2 & *3; VKORC1 -If allele variations, start with lower dose -Increased bleeding risk d/t decreased function of alleles and haplotypes & VKORC1 G>A variant |
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Codeine |
Cyp450 2D6 -Ultra-rapid or poor metabolizer, do not use -Ultra rapid = toxicity risk -Poor = lack of efficacy |
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Capecitabine |
DPD Deficiency -If positive, do not use -May increase toxicity |
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Azathioprine |
Thiopurine methyltransferase (TPMT) -if low/absent, start at low dose or alt. tx -Increased risk of severe, life threatening myelosuppression (intermediate activity also at risk) |
