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9 Cards in this Set

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CYP2D6: debrisoquin-sparteine polymorphism
metabolizes Codeine to active Morphine, also metablizes beta blockers, tricyclic antidepressants, dextromethorphan. .///

7% slow metablizers. So, slow effect of codeine on them. 30% east african fast metabolizers
slow metabolizers in Asian population..//substrate: omeprazole, phenytoin, diazepam etc. /// Omeprazole is proton pump inhib. so beneficial against H. pylori
slow metabolizers: enhance effects of S. Warfarin, phenytoin and Losartan. CYP2C9 is the primary metabolizer of Warfarin and hence these pts are oversensitive to this drug.
eliminates caffeine slowly
Dihydropyrimidine dehydrogenase
metabolizes 5-fluorouracil., can result in neurotoxicity
succinylcholine sensitity. >>> prolong action. Rare in asians and Africans.
N-Acytylation (NAT-2)
a Phase II reactant, acytylate isoniazid (INH), procainamide, sulfonamides, histamines etc.//

Slow metabolizers increases neurtotoxicity, chemical carcinogens from smoke, increased risk of bladder cancer. //

fast acytylators increased risk for colon cancer
Thiopurine methyl transferase (TPMT)
Thiopurine metabolized to active form, 6-thioguanine and inactivated by TPMT. So slow metabolizers end up with elevated 6-thioguanine, resulting in life-threatening myeolosupression.
Beta 2 adr. Receptor: Arg/Arg in venodilation desensitizes very quickly, but gives increased bronchodilator response relative to Gly/Gly or Arg/Gly. //

VKORC1: mutation causes insensitity to Warfarin, requiring more drugs.