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24 Cards in this Set
- Front
- Back
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Route of administration
Nature of Surface Blood Flow to Site of Administration Solubility of Drug Drug Concentration Dosage Form |
things that affect absorption
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Blood flow to tissues/circulatory status
Permeability of Capillaries to Drug Drug Reservoirs (Binding) Barriers to Drugs |
things that affect distribution
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drug reservoirs
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plasma binding
tissue binding |
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metabolism makes the drug more...
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water soluble or a metabolite
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Is the initial biotransformation of drug that produces a loss of pharmacologically ACTIVE MOLECULES, hence therapeutic action is Negligible
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hepatic first effect
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drugs with a tendency for hepatic first effect should be given....
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IV
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most common family enzyme
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CYP3A4
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When a large quantity of these enzymes are present...
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more metabolism can occur through this pathway.
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This increase in metabolism does what...
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rapidly decreases the amount of circulating drug.
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inhibiting enzymes in liver leads to... what kind of result?
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toxic!
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enzyme inducers... do what?
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increase metabolism and LESS drug in body
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To alkalize urine give what?
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NaHCOs- sodium bicarb
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To acidify urine give what?
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Vitamin C or Ammonium Chloride
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refers to the % of ACTIVE substances in a drug that is absorbed & becomes available to the TARGET TISSUE following administration
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bioavailability
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Most reliable & sensitive method of determining bioavailability
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plasma levels
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The rate at which drug molecules disappear from the circulatory system
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clearence
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affinity r/t....
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potency
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intrinsic activity r/t...
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efficacy
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strength of attraction
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affinity
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ability to stimulate receptor
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intrinsic activity
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how well the drug achieves its desired effect
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efficacy
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Drugs that can inhibit the action of a specific enzyme and alter a physiologic response.
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drug-enzyme interaction
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Drugs that act by mechanisms other than combining with receptor sites on cells.
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non receptor drug actions
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non receptor drug examples (2)
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osmotic diuresis
antacids |
