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50 Cards in this Set
- Front
- Back
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Most tablets are taken by the ____ route, and are prepared by _______
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oral
compression |
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9 types of tablets
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compressed tablets
multiple compressed tablets coated tablets Buccal and sublingual Molded tablets Rapid dissolving Chewable Effervescent Vaginal |
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what kind of tablet contains?
medication excipients diluent binder disintegrant glidant/lubricant |
Compressed tablets
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What is the purpose of diluent?
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filler, to add bulkiness to the medication
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an adhesive to maintain the integrity of the tablet
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Binder
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Helps the tablet break up in the body
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Disintegrant
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enhances powder flow, lubricates the machinery
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Glidant/ lubricant/ anti adherent
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Tablets subjected to more than a single compression. resulting in multiple layers or tablet core + shell
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Multiple compressed tablets
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What are the advantages of having multiple layers or a core+shell?
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controlled release
solve incompatibility unique appearance |
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4 types of coated tablets?
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Sugarcoated
Film coated Enteric Gelatin |
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Advantages of sugarcoating?
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water soluble sugar layer quickly dissolves in GIT.
Protection from environment Mask taste and odor |
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Disadvantages of sugarcoating?
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Time consuming
increase tablet weight + shipping cost High weight variation btw batches |
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in sugar coated tablets, waterproofing contains ____ or more layers to protect against moisture
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one
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waterproofing is made of _____or another polymer in alcohol
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shellac
poured or sprayed |
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how are coats dried?
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using warm air
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The subcoating on a sugar coated tablets consists of 3 to 5 coats of sugar based syrup with ____, ____, or ____
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gelatin, acacia, or PVP
for rounding the tablet and bonding the sugar coat |
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sugar coating consists of __-__ layers of thick syrup (usually _____)
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5-10
sucrose |
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After the sugar coat is dried with warm air, what else is done?
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finishing and coloring (coating with syrup+color)
Imprinting (printed or engraved) Polishing (carnauba wax/ beeswax) |
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what are the 3 types of film coated tablets?
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Film coating
Gelatin coating Enteric coating |
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thin skin like coat of plastic material
high resistance for destruction aq. or non-aq. coating |
Film coated tablets
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The coated tablet is the same weight, shape, and size as the uncoated
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Film coated tablets
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Only with non-aqueous films, ____ substance is added to the coating mixture to allow water to penetrate to the core
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alloying
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This coat facilitates swallowing
used as a tamper evident smaller size than equivalent capsule |
Gelatin coated tablets
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Used for delayed release tablets, intended to dissolve in the intestine
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Enteric coated tablets
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Have no first pass effect
Rapid absorption no disintegrants excipients must have acceptable taste |
Buccal and sublingual tablets
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this drug is placed under the tongue, can help with heat attacks
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Nitroglycerin tablets
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molded tablets are intended for ________ administration
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sublingual
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The base of a molded tablet consists of ____ and _____ 5-20%
alcohol from __-__% |
Lactose and sucrose
95-50% |
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dissolves in mouth btw 10 sec and 1 minute
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rapid dissolving tablets RDT
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gelatin, mannitol, citric acid, and sweetening agents are ___ ____ excipients in RDT
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water soluble
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What are the 2 techniques in making RDT's?
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Lyophilized (freeze drying) wafers
Compression |
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Fragile, porous, wafer like tablet
in blister package zydis technology |
Lyophilized wafers RDT
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Orasolv and durasolv technology
thin for a large surface area less fragile but take few seconds longer to dissolve |
Compression RDT
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Advantages of RDT's?
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quick onset of action
easy for kids and elderly admission without water |
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Disadvantages of RDT's
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difficulty in drug loading
taste masking high cost to make stabilizing is difficult |
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should have good taste and texture
compressed with min pressure mannitol is up to 50% of tab weight fruit flavors good for large tablets, tablets for kids |
Chewable tablets
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Effervescent tablets are make by ________ effervescent granules
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compressing
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what is the purpose of sodium hydrogen carbonate and citric acid?
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create CO2
alkaseltzer |
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Uncoated, bullet or ovoid tablets
local effect antibacterial |
vaginal tablets
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How are tablets tested?
6 ways |
weight variation
thickness hardness friability tests disintegration dissolution |
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Weight variation and content uniformity
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10 tablets
85%-115% of claimed weight relative standard deviation <6% |
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The total weight of the contents and capsule are recorded for weight variation
true or false |
false
only the contents |
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The force needed to break a tablet
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Hardness tablet testing
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What type of tablets are the hardest?
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buccal
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weight lost on exposure to slow rotation.
how well the tablets will withstand shipping accepted weight loss <1% |
Friability test
if 1 tablet breaks, the whole batch fails |
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a solution at ___degrees Celsius used to test disintegration time
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37
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time for disintegration?
uncoated sublingual buccal enteric |
30min
2min 4 hours enteric should resist disintegration for 1 hour in SGF |
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used for quality assurance
checking the bioequivalence indication |
dissolution testing
measure conc. of AI in solution over time |
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what types of fluid are used in dissolution tests?
how much? |
900ml
simulated intestinal fluid SIF simulated gastric fluid SGF |
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bioequivalence indication should be +/- __% for generic to brand
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15
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