Pharma- Msk

Front 1

Lipoxygenase pathway yields

Back 1

Leukotrienes

Front 2

This leukotriene is a neutrophil chemotactic agent

Back 2

LTB4

Front 3

These three leukotrienes promote bronchoconstriction

Back 3

LTC4, LTD4, LTE4

Front 4

Corticosteroids inhibit both

Back 4

Phospholipase A2 and synthesis of COX-2

Front 5

Another name for PGI2

Back 5

Prostacyclin

Front 6

____ inhibits platelet aggregation and promotes vasodilation

Back 6

PGI2

Front 7

Ketorolac is this type of medicine?

Back 7

NSAID

Front 8

Used to close a PDA

Back 8

Indomethacin

Front 9

5 toxicities of NSAIDs

Back 9

Renal damage
Fluid retention
Aplastic anemia
GI distress
Ulcers

Front 10

2 toxicities from COX-2 inhibitors

Back 10

Increased risk of thrombosis
Sulfa allergy

Front 11

Overdose of acetaminophen produces

Back 11

Hepatic necrosis

Front 12

Antidote for acetaminophen overdose (and mechanism)

Back 12

N-acetylcysteine (regenerates glutathione)

Front 13

Etidronate, pamidronate, alendronate, risedronate, and zoledronate are

Back 13

Bisphosphonates

Front 14

Mechanism of bisphosphonates

Back 14

Inhibit osteoclastic activity
Reduce both formation and resorption of hydroxyapatite

Front 15

3 uses of bisphosphonates

Back 15

Malignancy-associated hypercalcemia
Paget's disease of bone
Postmenopausal osteoporosis

Front 16

4 toxicities of bisphosphonates

Back 16

Corrosive esophagitis (except zoledronate)
Nausea
Diarrhea
Osteonecrosis of the jaw

Front 17

3 drugs for gout

Back 17

Colchicine (acute gout; alternative is indomethacin)
Allopurinol (chronic gout)
Probenecid (chronic gout)

Front 18

Mechanism of colchicine

Back 18

Binds and stabilizes tubulin to inhibit polymerization, impairing leukocyte chemotaxis and degranulation

Front 19

Mechanism of allopurinol

Back 19

Inhibits xanthine oxidase, decreasing conversion of xanthine to uric acid

Front 20

Mechanism of probenecid

Back 20

Inhibits reabsorption of uric acid in PCT (and secretion of penicillin)

Is a uricosuric

Front 21

Side effect of colchicine

Back 21

GI side effects

Front 22

Additional usage of allopurinol

Back 22

In lymphoma and leukemia to prevent tumor lysis associated urate nephropathy

Front 23

Allopurinol increases the concentrations of these 2 drugs

Back 23

Azathioprine and 6-MP (both normally metabolized by xanthine oxidase)

Front 24

Drug not to give in gout

Back 24

Salicylates (all but highest doses depress uric acid clearance w/ minor uricosuric activity)

Front 25

3 TNF-alpha inhibitors

Back 25

Etanercept
Infliximab
Adalimumab

Front 26

Etanercept is a

Back 26

Recombinant form of human TNF receptor that binds TNF (soluble form w/ Fc Ig)

Front 27

Chimeric anti-TNF Ab

Back 27

Infliximab

Front 28

Human anti-TNF Ab

Back 28

Adalimumab

Front 29

All TNF-alpha inhibitors should be given with

Back 29

MTX

Front 30

3 TNF-alpha inhibitors

Back 30

Etanercept
Infliximab
Adalimumab

Front 31

Etanercept is a

Back 31

Recombinant form of human TNF receptor that binds TNF (soluble form w/ Fc Ig)

Front 32

Chimeric anti-TNF Ab

Back 32

Infliximab

Front 33

Human anti-TNF Ab

Back 33

Adalimumab

Front 34

All TNF-alpha inhibitors should be given with

Back 34

MTX

Front 35

TNF alpha inhibitor that predisposes to infections (e.g. reactivation of latent TB)

Back 35

Infliximab