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64 Cards in this Set
- Front
- Back
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Gq receptors
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HAVe 1 M&M
H1 alpha1 V1 M1 M3 |
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Gi receptors
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MAD 2's
M2 Alpha2 D2 |
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Gs receptors
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all except HAVe 1 M&M and MAD 2's
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4 sympathetic GPCR
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alpha1
alpha2 beta1 beta2 |
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3 parasymp GPCR
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M1
M2 M3 |
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6 other GPCR
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D1
D2 H1 H2 D1 D2 |
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what type of GPCR is alpha1?
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q
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what type of GPCR is alpha2?
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i
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what type of GPCR is beta1?
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s
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what type of GPCR is beta2?
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s
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what type of GPCR is M1?
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q
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what type of GPCR is M2?
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i
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what type of GPCR is M3?
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q
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what type of GPCR is D1?
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s
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what type of GPCR is D2?
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i
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what type of GPCR is H1?
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q
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what type of GPCR is H2?
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s
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what type of GPCR is V1?
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q
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what type of GPCR is V2?
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s
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symp receptor that causes vascular smooth mm. contraction
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alpha-1
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non-symp receptor that causes vascular smooth mm. contraction
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V1
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increases pupillary dilator muscle contraction (mydriasis)
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alpha-1
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increase intestinal and bladder sphincter mm. contraction
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alpha-1
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decrease symp outflow
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alpha-2
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decrease insulin release
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alpha-2
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decrease lipolysis
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alpha-2
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increase plt aggregation
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alpha-2
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increase heart rate
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beta-1 + beta-2
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increase contractility
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beta-1 + beta-2
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increase renin release
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beta-1
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increase lipolysis
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beta-1 + beta-2
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cause vasodilation
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beta-2
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cause bronchodilation
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beta-2
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increase insulin release
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beta-2
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decrease uterine tone (tocolysis)
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beta-2
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ciliary mm. relaxation
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beta-2
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increase aqueous humor production
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beta-2
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type of muscarinic receptor that acts on CNS
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M1
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type of muscarinic receptor that acts on enteric NS
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M1
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mydriasis
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pupil dilation
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decrease HR
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M2
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decrease atrial contractility
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M2
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type of muscarinic receptor that acts on the heart
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M2
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increase exocrine gland secretions (lacrimal, gastric acid)
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M3
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increase gut peristalsis
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M3
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increase bladder contraction
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M3
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cause bronchoconstriction
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M3
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increase pupillary sphincter mm. contraction (miosis)
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M3
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causes contraction of ciliary mm. (accomodation)
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M3
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relaxes renal vascular smooth mm.
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D1
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modulates NT release, esp. in brain
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D2
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increases H2O permeability and reabsorption in collecting tubules of kidney
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V2
(V2 found in 2 kidneys) |
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Gq 2nd messenger
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Phospholipase C
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phospholipase C catalyzes
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lipids --> PIP2
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2 products of PIP2
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DAG
IP3 |
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DAG effect
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activates protein kinase C
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IP3 effect
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increases intracellular Ca++ --> smooth mm. contraction
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Gq receptor cascade
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Gq --> phospholipase C
--> catalyzes lipids --> PIP2 --> DAG + IP3 --> DAG --> protein kiase C --> IP3 --> increased intracellular Ca++ --> smooth mm. contraction |
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Gs action
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activates adenylyl cyclase
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Gi action
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inhibits adenylyl cyclase
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adenylyl cyclase action
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catalyzes ATP --> cAMP
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cAMP -->
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protein kinase A
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protein kinase A actions
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increase intracellular Ca++ (heart)
inhibit myosin light-chain kinase (smooth mm.) |
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adenylyl cyclase cascade
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catalyzes ATP --> cAMP --> protein kinase A
--> increases intracellular Ca++ (heart) --> inhibits myosin light-chain kinase (smooth mm.) |
