Pharm3 Nsaids

Front 1

Indicated for acute gout attack, ankylosing spondylitis, or rheumatoid arthritis:

Back 1

Indomethacin

Potent NSAID
More severe CNS and CV effects
Headache
Quite toxic in children (renal) and elderly (GI, neuro, BP, pancreas)

- used clinically to delay premature labor, reduce amniotic fluid in polyhydramnios, and to treat patent ductus arteriosus.

Front 2

True or False
All NSAIDs (except aspirin) may increase risk of MI or stroke; esp with previus CV problems or CHF

Back 2

TRUE

Front 3

Debated for its renal sparing quality, this NSAID acts through an active metabolite in the GI tract and is converted beck to inactive parent drug in the kidney

Back 3

Sulindac

Front 4

This super long lasting NSAID (45 hour half-life) takes 1-2 weeks to reach steady state and should not be used in elderly due to high incidence of bleeding.

Back 4

Piroxicam

Front 5

COX-1 or COX-2?
Indomethacin, Ibuprofen, Naproxen, Sulindac, Piroxicam

Back 5

Anti-Cox-1
some Anti-Cox-2 activity!

Front 6

If a drug does not inhibit thromboxane formation but does inhibit prostacyclin formation, what would you expect?

Back 6

Selective COX-2 Inhibitors:

Thromboxane causes a person to clot and vasocontrict. Inhibiting prostacyclin means nothing opposes that clotting or vasoconstriction.

This effect probably explains cardiovascular toxicity effects of Celecoxib.