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19 Cards in this Set
- Front
- Back
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This drug is identical to endogenous Cortisol
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Hydrocortisone
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What are the main uses of Hydrocortisone?
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To treat Addison disease and secondary/tertiary cortisol insufficiency
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This drug is a synthetic mineralcorticoid with some glucocorticoid activity
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Fludrocortisone
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This drug is used in a suppression test to properly diagnose Cushing syndrome
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Dexamethasone
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How do you interpret the results of a Dexamethasone suppresion test?
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- If Dexamethasone suppresses cortisol release, then the Cushing syndrome is pituitary-dependent
- If Dexamethasone does not suppress coritsol release, then the Cushing syndrome is due to an adrenal tumor |
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What are the two uses of Beclomethasone?
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- Inhaled to reduce allergies
- Injected in a pregnant mother to accelerate fetal lung function |
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What are the advantages of inhaled Beclomethasone in the treatment of allergies?
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- It minimizes systemic effects
- It reduces or eliminates the need for oral steroids |
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What is the proper dosing of Beclomethasone in the acceleration of fetal lung function?
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Administer a first dose IM to the mother 48 hours before birth. Administer a second dose IM to the mother 24 hours before birth.
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Name the two inhaled adrenocorticosteroids used in the treatment of allergies
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Beclomethasone and Triamcinolone
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- What drug is now routinely prescribed for anyone on long-term oral glucocorticoid therapy?
- Why |
- Bisphosphanate (Fosamax)
- To counteract the adverse effect of osteoporosis |
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Mineralcorticoid treatment may cause what condition that requires a specific supplement?
What is that supplement? |
- Hypokalemia
- Potassium supplements |
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This inhibitor of adrenocorticoid biosynthesis was formerly used in the diagnosis of Cushing syndrome
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Metyrapone
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This drug reduces the synthesis of all hormonally active steroids and has been used in the treatment of breast cancer to reduce/eliminate androgen and estrogen production
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Aminoglutethimide
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Which drug has largely replaced Aminoglutethimide in the treatment of breast cancer?
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Tamoxifen
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This antifungal drug strongly inhibits all gonadal and adrenal steroid hormone synthesis and is used in the treatment of Cushing syndrome
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Ketoconazole
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What are the useful mechanisms of action for Spironolactone?
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- It competes for the mineralcorticoid receptor
- It antagonizes the synthesis of aldosterone and testosterone - These inhibit sodium reabsorption and reduce testosterone levels |
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What is Spironolactone used to treat?
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- Hyperaldosteronism
- Hirsutism in women |
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What are the major adverse effects of Spironolactone
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- Hyperkalemia
- Gynecomastia |
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What are the main benefits of Eplerone?
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- It has the same mineralcorticoid and aldosterone antagonist properties
- It avoids adverse effects of Spironolactone - It is also an approved antihypertensive |
