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5 Cards in this Set
- Front
- Back
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What drugs are useful against CMV and what are their toxicities?
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Ganciclovir
* BM suppression * CNS effects (confusion) * retinal detachment Foscarnet * nephrotoxicity quite frequent (treat with hydration) * little BM suppression! * not well tolerated by many (?) IV-only |
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How do neurominidase inhibitors work?
What are they called? What are their limitations? |
Inhibit both Flu A and B!
Prevents new flu viruses from being released from infected cells. Oseltamivir Zanamivir Administer early or prophylactically. Shortens disease by 1-2 days. Decrease bacterial complication risk! Avoid in pregnancy. Neuropsychiatric abnormalities reported (esp. children). |
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What are the NRTI's?
How do they work? |
Zidovudine
Didanosine Thymidine analogs * are phosphorylated * incorporated into HIV DNA * terminate viral DNA by 3'-OH blocked by azido group Reciprocal changes in sensitivity between these drugs. "ping-pong effect" Little cross-resistance between them. |
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What are the advantages to protease inhibitors?
What are their limitations? |
They reduce the plasma HIV mRNA to minimally detectable levels, but the virus still proliferates inside CD4 cells.
Rare cross-resistance makes good combo! P450 drug reactions likely. (may use ritonavir to block) |
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How does Acyclovir work?
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Analog of deoxy-guanosine
Phosphorylated by herpes thymidine kinase to form triphosphate. * inhibits DNA pol * incorporated into viral DNA * terminates DNA chains |
