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15 Cards in this Set
- Front
- Back
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GnRH agonist
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Leuprolide,
Nafarelin Used: diagnostically prostate carcinoma endometriosis |
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5-alpha-reductase inhibitor
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Finasteride
Used: BPH hirsutism male pattern baldness |
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Androgen receptor blockers
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Flutamide
Bicalutamide Used: Prostate cancer in conjunction with GnRH agonist (leuprolide, nafarelin) |
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Blocks testesterone conversion to DHT
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Finasteride
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Weak antagonist at androgen receptor and a weak synthesis inhibitor, used to treat hirustism.
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Spironolactone
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What is Cyp19?
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p450 enzyme
Estrogen aromatase Convert Testost to Estradiol, mainly in liver and adipose. |
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SHBG
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steroid hormone binding globulin
binds 65% of androgens Increased by estrogen, TH, cirrhosis |
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NR3A
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androgen receptor (nuclear)
DHT binds with higher affinity and activates more efficiently than testosterone. |
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Effects of Testosterone
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Internal genitalia
Skeletal muscle Erythropoiesis (hormone feedback, sperm, sexual differentiation) |
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Effects of Dihydrotestosterone
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External genitalia
Hair follicles (prostate, virilization, sexual maturity at puberty, baldness) |
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Treatment of angioedema
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Stimulate the synthesis of C1-esterase inhibitor in the liver.
Chronic treatment using androgens. |
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Adverse effect:
Hepatocellular cancer |
17-alpha alkylated androgens
(liver damage: cholestasis, hepatitis, cysts) |
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Treatment of prostate carcinoma
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orchiectomy or large doses of estrogen
Flutamide/bicalutamide with Leuprolide/Nafarelin |
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Pulsatile GnRH causes what?
Continuous causes what? |
release of LH -> increased testosteron
hypogonadism |
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Which drug elevates testosterone for about a week?
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Leuprolide
Nafarelin |
