Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
*** #1 - Thyroid and Anti-thyroid Drugs***
|
***Thyroid and Anti-thyroid Drugs***
|
|
Levothyroxine:
what decreases its absorption? what drugs' effects are increased by thyroxine? what drugs' effects are decreased by thyroixine? uses? (3) |
calcium carbonate decreases its absorption
increases: warfarin, TCAs, amiodarone decreases: oral contraceptives, cholestyramine, rifampicin uses: hypothyroidism, myxedema, coma, nodular thyroid disease |
|
Thiourylenes:
Two important drugs? MOA? What's a mechanistic advantage of PTU? What type of inhibition? Which drug is more potent? Which drug is preferred for pregnant women and nursing moms? Adverse reactions? |
Propylthiouracil (PTU), Methimazole, (Carbimazole not in U.S.)
MOA: inhibits iodine organification (i.e. inhibits the peroxidase catalyzed reactions: iodination and coupling) PTU advantage: inhibits peripheral conversion of T4-->T3 the inhibition is IRREVERSIBLE Methimazole is 10X more potent; PTU has shorter t1/2 Both drugs cross placental barrier, but PTU is preferred b/c it crosses placenta less and into breast milk less Minimal # of pts get S/Es: agranulocytosis (sign: sore throat) granulocytopenia (get leukocyte counts) skin rash hypothyroidism |
|
Iodide:
MOA? uses? (2) when not to use it? must use with? |
MOA: inhibits iodide uptake at HIGH DOSES; in time, lowers synthesis of I- pump so you lose I- in cells
Uses: pre-op treatment; thyroid storm Don't use: prior to radioactive iodide treatment** Must use with: PTU or methimazole |
|
Radioactive iodine:
alternative to what? how is it given? what do you do after giving it? who can you use it in? disadvantage/side effect? |
Radioactive iodine:
alternative to surgery give Na+ 131-I orally use Beta and Gamma radiation to destroy thyroid gland used in adults >35, but not in child-bearing age females may cause delayed hypothyroidism (due to overtreatment) |
|
Beta-blockers: (i.e. Propranolol)
why are they used for hyperthyroidism? what do they do? |
Beta-blockers: (i.e. Propranolol)
hyperthyroidism causes increased # of B-adrenergic receptors in heart --> high HR and contractility Beta-blockers help against cardiac S/Es of hyperthyroidism; also lowers conversion of T4 to T3 |
|
Anion inhibitors:
uses in hyperthyroidism? |
Anion inhibitors:
used as diagnostic tool; high toxicity |
|
What drug class inhibits coupling?
|
Thiourylenes
|
|
What drug class inhibits hormone action in periphery?
|
Beta-blockers (Propranolol)
|
|
Preferred drugs for treatment of thyroid storm?
|
PTU* (blocks T4 --> T3)
others: high dose iodide Beta-blockers IV hydrocortisone Acetaminophen (for fever) |
|
*** #2 - Geriatric Psychopharm***
|
*** #2 - Geriatric Psychopharm***
|