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76 Cards in this Set

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Tolbutamide
Sulfonylureas - disulfarm like effect. Close K+ channel in B cell membrane so cell depolarizes. It depolarizes b/c of a trigger of insulin due to increase in Ca+ influx. Stimulates endogenous insulin.
Chlorpropamide
Sulfonylureas - disulfarm like effect. Close K+ channel in B cell membrane so cell depolarizes. It depolarizes b/c of a trigger of insulin due to increase in Ca+ influx. Stimulates endogenous insulin.
Glyburide
Sulfonylureas - hypoglycemia. Close K+ channel in B cell membrane so cell depolarizes. It depolarizes b/c of a trigger of insulin due to increase in Ca+ influx. Stimulates endogenous insulin.
Glimepiride
Sulfonylureas - hypoglycemia. Close K+ channel in B cell membrane so cell depolarizes. It depolarizes b/c of a trigger of insulin due to increase in Ca+ influx. Stimulates endogenous insulin.
Glipizide
Sulfonylureas - hypoglycemia. Close K+ channel in B cell membrane so cell depolarizes. It depolarizes b/c of a trigger of insulin due to increase in Ca+ influx. Stimulates endogenous insulin.
Metformin
Biguanide. Possibly decrease gluconeogensis. Lactic Acidosis. Can be used in type 1 diabetic.
Pioglatozone, rosiglatizone... "azones"
Increase target cell response. Hepatotoxicity.
Acarbose
alpha glucosidase inhibitor. Inhibit brush borderl alpha glucosidase to delay sugar hydrolysis and glucose absorption. Side effect is GI issues.
Miglitol
alpha glucosidase inhibitor. Inhibit brush borderl alpha glucosidase to delay sugar hydrolysis and glucose absorption. Side effect is GI issues.
Sibutramine
Sympathomimetic serotonin and norepinephrine reuptake inhibitor. Weight loss.
Propylthiouracil
Used for hyperthryoidism. SE is agranulocytosis and aplastic anemia. Inhibits thhyroid harmone sythensis and T4 -> T3 conversion in periphery.
Methimazole
Used for hyperthryoidism. SE is agranulocytosis and aplastic anemia. Inhibits thhyroid harmone sythensis and T4 -> T3 conversion in periphery.
Levothyroxine
Used for hypothyroidism. Thyroxine replacement (T4). Tachy, heat intolerence, tremors.
Triiodothyronine
Used for hypothyroidism. Thyroxine replacement (T4). Tachy, heat intolerence, tremors.
GH
Turners syndrome treatment
Somatostatin (octreotide)
Acromegaly, carcinoid, gastrinoma, glucagonoma.
Oxytocin
Stimulate labor, uterine contractions, milk let down, controls uterine hemorrhage.
Triamcinolone
Tx. Addisons. Decreases leukotrienes and prostaglandins by inhibiting phospholipase A2 and expression of COX2. SE iatrogenic cushings syndrome, osteoperosis, adrenocortical atrophym peptic ulcers.
Dexamethason
Tx. Addisons. Decreases leukotrienes and prostaglandins by inhibiting phospholipase A2 and expression of COX2. SE iatrogenic cushings syndrome, osteoperosis, adrenocortical atrophym peptic ulcers.
Beclomethasone
Tx. Addisons. Decreases leukotrienes and prostaglandins by inhibiting phospholipase A2 and expression of COX2. SE iatrogenic cushings syndrome, osteoperosis, adrenocortical atrophym peptic ulcers.
Hydrocortisone
Tx. Addisons. Decreases leukotrienes and prostaglandins by inhibiting phospholipase A2 and expression of COX2. SE iatrogenic cushings syndrome, osteoperosis, adrenocortical atrophym peptic ulcers.
Prednisone
Tx. Addisons. Decreases leukotrienes and prostaglandins by inhibiting phospholipase A2 and expression of COX2. SE iatrogenic cushings syndrome, osteoperosis, adrenocortical atrophym peptic ulcers.
Quinidine
Class 1A FAST NA+ channel blocker. M2 anatagonist working on the SA and AV node. Increase AP duration, ERP, QT. SE is cinchonism in toxicity, thrombocytopenia, torsades de pointes. SLE like effects too.
Procainamide
Class 1A FAST NA+ channel blocker. M2 anatagonist working on SA and AV node. Increase AP duration, ERP, QT. SE - reversible SLE like syndrome.
Disopyramide
Class 1A FAST NA+ channel blocker. M2 anatagonist working on SA and AV node. LONGEST HALF LIFE OF ALL IN ITS CLASS. Increase AP duration, ERP, QT.
Amiodarone
Class 1A FAST NA+ channel blocker. Increase AP duration, ERP, QT. Also, K+ channel blocker. SE check LFTS, TFTS, PFTS, pulomonary fibrosis, hepatoxicity, hypo or hyperthyroidism. Has idoinine. Blue smurf syndrome.
Lidocaine
Class 1B FAST Na+ channel antagonist. Works more on closed channels though and blocks Na influx.
Use - ischemic or depolarized purkinje or ventricular tissue. Acute ventricular arrythmias post MI.
Decreases AP duration.

Toxicity - vertigo, twitching, drowsy, disoriented, convulsions, resp depression.
Mexiletine
Class 1B FAST Na+ channel antagonist. Works more on closed channels though and blocks Na influx.
Use - ischemic or depolarized purkinje or ventricular tissue. Acute ventricular arrythmias post MI.
Decreases AP duration.
LONGEST HALF LIFE IN CLASS
PO
Tocainide
Class 1B FAST Na+ channel antagonist. Works more on closed channels though and blocks Na influx.
Use - ischemic or depolarized purkinje or ventricular tissue. Acute ventricular arrythmias post MI.
Decreases AP duration.
PO
Fecainide
Class 1C. FAST Na+ channel antagonist. V tach to VF and intractable SVT.

Significantly prolongs refractor period in AV node. Contraindicated post MI. Normal ERP
Ecainide
Class 1C. FAST Na+ channel antagonist. V tach to VF and intractable SVT.

Significantly prolongs refractor period in AV node. Contraindicated post MI. Normal ERP
Propafenone
Class 1C. FAST Na+ channel antagonist. V tach to VF and intractable SVT.

Significantly prolongs refractor period in AV node. Contraindicated post MI. Normal ERP
Propranolol
non selective b1 and b2 adrenergic receptor antagonist.
Metoprolol
non selective b1 and b2 adrenergic receptor antagonist.
SE dyslipidemia.
Esmolol
non selective b1 and b2 adrenergic receptor antagonist.
Sotalol
non selective b1 and b2 adrenergic receptor antagonist. Also, a K+ channel antagonist.
SE - torsades and excess B block.
Class 2 and 3.
Ibutilide
Class 4. Blocks K+ efflux. SE like Amiodarone.
Bretylium
Class 3. Blocks K+ efflux. SE like Amiodarone.
Amiodarone
Class 3 and 1a. Alpha adrenergic receptor antagonsist for peripheral vasodilation.
Verapamil
Class 4. L-type Ca+ channel antagonist. Decreases conduction velocity. Increase ERP, PR. Prevents nodal arrythmias.
SE - constipation flushing, edema.
Diltiazem
Class 4. L-type Ca+ channel antagonist. Decreases conduction velocity. Increase ERP, PR. Prevents nodal arrythmias.
SE - constipation flushing, edema.
"tidines"
Cimetidine, ranitidine, famotidine, nizatidine
H2 receptor antagonist. Decrease H+ secretion by parietal cells. Cimetidine INHIBTIS p450 and decrease renal excretion of creatine.
Omeprazole
H+/ATPase pump in stomach parietal cells inhibited. ZE syndrome.
Lansoprazole
H+/ATPase pump in stomach parietal cells inhibited. ZE syndrome.
Allows HCO3- secretion to reestablish pH gradient in the mucous layer
Bismuth and sucralfate.
Misoprostol
A PGE1 analog. Decreases acid production and increases production and secretion of gastric mucous layer. Maintains patent ductus (indomethicin closes it).

toxicity is diarhea and abortifictant in pregancy.
Pirenzepine
Block m1 receptors on the ECL cell which decreases histamine release. M3 receptors on parietal cells will decrease H+ secretion too.

SE dry mouth, tachycardia, difficulty focusing eyes.
Propantheline
Block m1 receptors on the ECL cell which decreases histamine release. M3 receptors on parietal cells will decrease H+ secretion too.

SE dry mouth, tachycardia, difficulty focusing eyes.
Infliximab
A monoclonal antibody to TNF-alpha which is a pro inflammatory cytokine.

used in crohns and RA

toxicity - resp. infection, fever, and hypotension.
Sulfasalzine
Used in UC and crohns. A combination of sulfapyridine (antibacterial) and mesalmine (anti-inflammatory). Activated by colonic bacteria.

Sulfonamide toxicity, oligospermia.
Odansetron
5-Ht3 antagonist. Power central acting antiemetic.

Controls vomitting in cancer and post op patients.

toxicity are headache and constipation.
Bromocriptine
Parkinsons drug. ergot alkoid so can cause SLE like syndrome. Also a partial dopamine agonist.
Metoclopramide
D2 receptor antagonist. Increased parkinson effects. Restlessness, etc. etc. Drug interaction with digoxin and diabetic agents. Contraindicated in patients with bowel obstruction.

Diabetic and post opwer gastroparesis.
Pramipexole
Parkinsons treatment. Agonize dopamine receptor
Ropinirole
Parkinsons treatment. Agonize dopamine receptor
Amantadine
Parkonsons treatment. increase dopamine release.
Selegiline
Parkosons treatment. Selective MAO B inhibitor. Prevent dopamine breakdown.
Entacapone
Parkosons treatment. COMT inhibitor that prevents breakdown of dopa decarboxylase.
Tolcapone
Parkosons treatment. COMT inhibitor that prevents breakdown of dopa decarboxylase.
Benztropine
Parkonsons treatment. Antimuscarnic to imrpove tremor and rigidity. Curbs cholinergic activity.
Sumatriptan
For Acute migraines and cluster headaches. 5-HT1D agonist. does vasoconstriction.

Toxicity - coronary vasospams and mild tingling. contraindicated in people with CAD or prizmetals angina.
Valproic acid
DOC for tonic clonic seizures. GI distress, rare but fatal hepatoxicity. NTBs, tremor and weight gain.
Carbamazepine
Diploplia, ataxia, agranulocytosis, aplastic anemia, liver toxicity. induces P450.
Ethosuximide
DOC for absent seizures. GI distress, lethargy, headache, urticaria, steven johnsons syndrome.
Phenytoin
Use dependant blockade of Na+ channels, inhibition of gluatmated release from excitarory presynaptic neuron.
Class 1B antiarrythmatic.

SE - Nystagmus, diploplia, ataxia, gingival hyperplasia, hisutism, megaloblastic anemia, SLE, teratogenic,induced P450. decreased folate absorption and fetal hydantion syndrome.
Halothane
inhaled anesthetic that causes hepatoxicity.
Methyoxyflruane
inhaled anesthetic that casues nephrotoxicity.
Increase frequency of chloride channel opening. Facilitates GABAa action in this way.
Benzos.

"Lams" and "pams" also chlordiazepoxide
chlordiazepoxide
benzo
benzo OD
flumazenil
Increase duration of chloride channel opening. facilitates GABAa action in this way.
Barbituates.

"barbital" also thiopental (used for anesthesia.
barbituates OD
naloxone.
Endoscopy drug
midazolam
Short operative procedures and rapid anesthesia with less side effects.
propofol
barbs or benzo which one is safer?
benzos hence why its used in sleep terrors, detox etc.
Malingant hyperthermia treatment
Dantrolene. MAO - prevents release of Ca+ from the SR.