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10 Cards in this Set
- Front
- Back
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Tetrodotoxin and Saxitoxin?
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sodium channel blockers
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Batrachotoxin?
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stimulates sodium influx
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Alpha-bungarotoxin?
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neuromuscular blockade
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Latrotoxin?
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uncontrolled release of acetylcholine (black widow spider venom)
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clostridium botulinum toxin?
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blocks release of acetylcholine
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Phospholipase C?
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its activation via a Gq protein leads to IP3 production and calcium release for smooth muscle contraction! (C for Ca and contraction)
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Which receptors work through Phospholipase C activation?
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M3
alpha 1 thromboxane etc. |
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Which beta and which muscarinic receptors have opposing effects on adenylyl cyclase?
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beta 1 (activates via Gs)
M2 (inactivates via Gi) |
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Norepinephrine?
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-both alphas, beta1
-affects alphas most -orally ineffective and poor absorption by SQ and IM -metabolism by MAO and COMT |
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Norepinephrine uses?
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-to increase blood pressure in circulatory depression
-has cardiotonic effect used for CHF to improve left ventricular contractility -intense, local vasospasm to alleviate local hemorrhage |
