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7 Cards in this Set
- Front
- Back
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Type 1 - Hyperchylomicronemia
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Increased blood levels of Triglycerides and Cholesterol;
treat with diet and lifestyle |
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Type 2a- Hypercholesterolemia
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Increased LDL leads to elevated serum cholesterol levels;
treat with statins (atorvastatin) and/or nicotinic acid (Statins reduce LDL levels the most) |
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What lipid-lowering agent has the greatest effect on increasing HDL cholesterol?
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Niacin
Inhibits lipolysis and reduces hepatic VLDL secretion Side effects: Red flushed face (which can be decreased by aspirin); Possible Myopathies |
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Type 4- Hypertriglyceridemia
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Increased VLDL leads to elevated serum Triglyceride levels;
treat with statin +/- fibrates (Fibrates decrease Triglyceride levels the most) |
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What lipid-lowering agent has the greatest effect on decreasing LDL cholesterol?
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Statins
Inhibit HMG-CoA reductase which is responsible for making Mevalonate (the precursor of cholesterol) |
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What lipid-lowering agent has the greatest effect on decreasing LDL cholesterol?
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Statins
Inhibit HMG-CoA reductase which inhibits production of mevalonate (the cholesterol precursor). |
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What lipid-lowering agent has the greatest effect on decreasing Triglycerides?
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Fibrates
Upregulate Lipoprotein Lipase (LPL) which increases Triglyceride (TG) clearance. |
