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10 Cards in this Set

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  • Back
LD 50
the dose of a substance that kills 50% of subjects
ED 50
the dose required to achieve a half-maximal effect
TD 50
the dose required to achieve 50% toxicity
therapeutic index
LD50/ED50 or TD50/ED50, larger therapeutic index=safer drug
threshold dose
the dose below which some compounds are considered to be non-toxic (NOAEL)
acceptable daily limit
used to determine the safe level of additives and contaminants, usually some factor such as 1/100 to 1/1,000 of the NOAEL
tetratogenicity
the study of congenital defects
Category A=proven to be safe
Category B=animal no risk, studies in women unavailable OR adverse effect in animal not proven in women
Category C=adverse effect in animal not proven in women OR no studies available...drug only given if potential benefit justifies the potential risk
Category D=positive evidence of human risk, but benefits may be acceptable in life threatening or serious disorder
Category X=risk of drug clearly outweighs any possible benefit
ABCD of emergency management
airway, breathing, circulation, dextrose
cholinergic or anticholinesterase syndrome
due to organophosphate and carbamate insecticides, peripheral effects due to muscarinic and nicotinic receptor stimulation
anticholinergic syndrome
caused by atropine, scopolamine, tricyclic antidepressants, antihistamines, jimson weed