Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Isoniazid Mech and SPec
|
Mech: Inhibits mycolic acid synthesis
Spec: M. Tuber, M.kansasii, can be used for prophylaxis |
|
|
Isonizaid pharmacokinetics and SE
|
Enters CNS, is acetylated, adjust for renal function.
SE: Hepatotox which increases with age. Peripheral neuritis if not given with pyridoxine (vit b6). |
|
|
Fast and slow acetylators
|
Fast = japs and escimos
SLow = whites, jews, africans, and scandinavians. |
|
|
Rifampin/Rifabutin Mech and spec
|
Mech: DNA dependent RNA pol inhibitor.
Spec: M tuber, M marinum, M kansasii, M leprae, MAC. |
|
|
Rifampin/Rifabutin pharmacokinetics and SE
|
Enter CNS. Both metabolized by liver, excreted billiary but rifabutin also renal excretion. Have to adjust does if liver failure for rifampin only. Both effect p450, but rifampin is worse.
SE: Hepatitis if given with isoniazid, orange/red urine saliva tears. |
|
|
Ethambutol Mech and spec
|
Mech: Inhibits mycolic acid
Spec: M. tuber, M, Kansasii, MAC, M. marinum. |
|
|
Ethambutol pharmacokinetics and SE
|
No CNS, renal excretion.
SE: Optical neuritis (cant tell green from red), gout |
|
|
Pyrazinamide Mech and Spec
|
Mech: Inhibits mycolic acid synth.
Spec: M tuber |
|
|
Pyrazinamide pharmacokinetics and SE
|
CNS, Renal excretion.
SE: Counter indicated in liver failure, dose related hepatits. |
|
|
Clofazimine Mech and Spec
|
Mech: Inhibits template function of DNA
Spec: M leprae |
|
|
Clofazimine pharmacokinetics and SE
|
Billiary/fecal excretion.
SE: Brownish pink coloring of skin, cornea, urine, Not for Preg. |
|
|
Dapsone Mech and spec
|
Mech: Inhibits DH synth
Spec: M leprae |
|
|
Dapsone pharmacokinetics and SE
|
Renal excretion.
SE: Hemolytic anemia in G6 deficient. Get sulfone syndrome - dermatitis. |
|
|
M Tuber DOC
|
Isoniazid, rifampin (rifabutin in AIDS), pyrazinamide, ethamnutol, strepto mycin
|
|
|
MAC DOC
|
Clarithromycin, azithromycin, ethambutol, rifabubtin
|
|
|
M Kansasii DOC
|
Isoniazid, rifampin, ethambutol
|
|
|
M marinium DOC
|
rifampin, ethambutol
|
|
|
M leprae DOC
|
dapsone, rifampin, clofazimine
|
|
|
M fortuitum DOC
|
Amikacin, doxycycline
|
