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19 Cards in this Set
- Front
- Back
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For what drugs is Mebendazole the DOC?
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Ancyclostoma duodenale
Ascaris lumbricoides Necator americanus Trichuris trichiuria |
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For what drugs is albendazole the DOC?
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Ancyclostoma duodenale
Ascaris lumbricoides Necator americanus Trichinella spiralis (GI phase, no drug for the muscle phase) Cystercosis of Taenea solium Given with diethyl carbamazine or ivermectin for Wuchereria Bancrofti. |
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DOC Enterobius vermicularis?
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Pyrental pamoate
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DOC Strogyloides stercoralis
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Ivermectin
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DOC Wuchereria Bancrofti
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Ivermectin or diethylcarbamazine + albendazole
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DOC Onchocerca volvulus
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Ivermectin
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DOC Shistosomes and Tape worms
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Praziquantel
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Mebendazole Mech
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Uncouples OxPhos and blocks microtubule polymerization. Only works in GI
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Mebendazole SE, CSN
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SE: Diarrhea, abdominal pain
CNS: no |
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Albendazole Mech
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Uncouples OxPhos and blocks microtubule polymerization. Only works in GI
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Albendazole SE, CNS
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SE: NV
CNS: yes |
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Pyrantel Pamoate Mech and spec
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Mech: Depolarizing NM blocker causing persistent activation of nicotinic receptors and paralysis.
Spec: Enterobius vermicularis |
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Pyrantel pamoate SE
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GI probs, NM block
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Diethylcarbamazine Mech and spec
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Mech: Sensitize to phagocytosis
DOC: Wuchereria bancrofti. Given with albendazole |
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Diethylcarbamazine SE
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GI probs, general weakness, Mazzotti Rx - Onochocerca volvulus, chorioretinitis, puritis
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Praziquantel Mech and spec
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Mech: Increases parasite membrane permeability to calcium causing severe muscle contraction.
Spec: All tapeworms and schistosomes |
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Praziquantel SE
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Works with p450, depressed liver function may cause dose adjustment. Counterindicated in patients with ocular cysticercosis.
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Ivermectin Mech and spec
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Mech: Activates glutamate and GABA gated chloride leading to tonic paralysis of muscles.
Spec: Onchocerca volvulus, Strongyloides stercoralis, Wuchereria bancrofti. Given with albendazole |
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Ivermectin SE
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CNS tox, Mazzotti Rx - fever, puritis.
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