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13 Cards in this Set

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  • Back
What are the Thyroid hormones?
T3=Triiodothyronine
T4=Tetraiodothyronine
Physiologic effects of Thyroid Hormones?
-increased CO
-increased HR
-increased RR
-increased BMR
-Brain Development
-Thickens Endometrium
Which one is given for Thryoid replacement?
T4
Hyperthryroidism?
-Grave's Disease
-may be subclinical (low TSH/normal T3-T4)
What is overt hyperthroidism?
-Low TSH
-High free T3 and T4
What is the most common cause of hyperthyroidism?
-Grave's disease
-Autoimmune
(antibodies attack the thyroid gland and cause a goiter and overprod. of thryoid hormone).
TX of Grave's Disease?
1) reduce the amt of functional thyroid tissue
2) inhibit thryoid homrone secretion/production
3) Adjunctive tx(control sxms)
Poylthiouracil (PTU)
-Older drug
-A thioanamide compound which inhibits biosynthesis of thyroid hormone
-Inhibits T4-T3 conversion
-Use T4/T3/TSH as levels as guides for taper
PTU dosing
6 weeks tx for a eurothyroid condtion
-long term treat 1-2years
-max dose 1200 mg a day
-usu in 300-600 mg/daily in divided doses 3
PTU Warnings
ADX
Monitor PT/INR
Preg cat D
ADX: agranulocyctosis
priuritic maculopapular rash, artharalgia, leukopenia, fever.
N&V, epigastric distress, headache, etc with OD
Methimazole(Tapazole)
A thionamide compound which inhibits biosynthesis of thyroid compounds.
-Same MOA as PTU
-10X more potent and acts faster and better tol. than PTU.
Methiamzole cont:
-Both drugs can induce fetal goiter and hypothyroidisim.
-Long term tx-12-24 months
-About same remision rate as PTU
Methiamzole
Contraindications/ADX
-Breast feeding/pregnancy
-PTU better for pregnancy
-Cross sensitivity between this and PTU
ADX: See PTU