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39 Cards in this Set

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Which drug has NMDA receptor blocker and weak carbonic anhydrous inhibition?
Toprimate(topromax)
which AEDs cause aplastic anemia?
Carbamazepine
Felbamate
which AED is not effective with absence seizures?
Phenytoin is not effective
What is the NTW for:

Phenytoin
Phenobarb
Valproic Acid
Carbamazepine
Gabapentin
Lithium
Phenytoin 10-20 mcg/ml
Phenobarb 10-40 mcg/ml
Valproic Acid 50-150 mcg/ml
Carbamazepine 4-14
Gabapentin 4-16
Lithium 0.8-1.2 meq/L
Which Antidepressive drug works on Serotonin and Norepi?
Venlafaxine(effexor)-causes HTN
Which drugs increase lithium?
Theophyline
Thiazides
ACEI
NSAIDS
which drugs decrease levels of carbamazepine?
Felbamate
Phenytoin
Phenobarb
Which drugs decrease levels of phenytoin?
Valproic Acid
Carbamazepine
Which drugs increase levels of phenytoin?
Felbamate
Methsuximide
Phenobarb (can inc or decrease)
which drugs decrease levels of valproic acid?
Carbamazepine
Lamotrigine
Phenobarb
Primidone
Phenytoin
What's the thyroid DOC in pregnancy? Dose?
PTU: 75mg QID initial then
100mg/day in divided doses
what are the Cardiac S.E of TCAs?
CHF
Heart block
Hypotension
Prolong QT
Tachy
which drugs cause Agranulocytosis?
Clozapine-atypical antipsych
Methimazole
PTU
TCAs
what are the S.E of Oxcarbamazepine?
Hyponatremia
Blood dyscrasias
Treatment for BZD OD
Flumazenil

0.5mg IV once
what advantages does Fosphenytoin have over phenytoin
IM or IV dosing
Phlebitis is minimized
Faster infusion
Can mix in D5 or NS
What are the S.E of BZDs
Sedation
Euphoria
Addiction

Cognitive impairment(confusion,memory)
Ataxia
Withdrawal symptoms
Which 2nd Gen. AEDs are renally eliminated
Gabapentin
Topromax
what are the side effects of topromax
paresthesias
psychomotor slowing
hyperthermia
renal stones
metabolic acidosis
this drug modulates release of excitatory NTs(glutamate, substance P, Noradrenaline)
Pregabalin (lyrica)

Unique: site of action is in brain and spinal cord

S.E: dizziness and somnolescence
Which Atypicals are rapid acting? IM or IV?
Zyprexa
Abilify
Geodone-monitor EKG(QT)
Risperdal(tablet form)
Tx for bipolar (euphoric/hypomanic/mania)
Lithium 400mg tid
Zyprexa 5mg/day
Tx for agitation
Haldol and Ativan
what is the best drug to control schizophrenia?
clozapine (must have weekly CBC); due to agranulocytosis
If you prescribe Haldol long term what should you also prescribe?
Cogentin to counteract the high EPS symptoms
Name some S.E of typical antipsychotics
Tardive dyskenisias
Tremors
Restlessness

Treat with ACHs(benadryl)
What is the treatment for Neuroleptic malignant syndrome?
Dantrolene
what is the advantage of Atypicals?
< EPS
Block serotonin receptors
what is the clinical presentation of Addison's?

How do you treat?
Hypoglycemic
Hyperkalemia
Hyponatremia (<135)
Dehydration

Fludrocortisone: 0.05mg/daily
Hydrocortisone: 40mg AM/20mg PM
How do you treat Graves?
what do you monitor?
Methimazole 30mg/daily initial
5mg/daily maintenance

Monitor: LFT, CBC, GI
pregnant woman with hyperthyroidism, how do you treat?

What do you monitor?
PTU
75mg QID initial
100mg/day in divided doses

monitor: LFT, CBC, GI sx
Which typical antipsychs have the highest EPS Sx
Haldol
Prolixin

Treat with Benadryl or Cogentin
Which TCAs have active metabolites?
Primary:
Amoxapine

Sencondary:
Nortriptylline
Desipramine


Tertiary:
Doxepin
Imipramine
Amitriptyline
what can happen if you administer an SSRI or TCA with a MAOI?
potential fatal reaction; you need a 2 wk washout period with MAOIs
Why are TCAs not the DOC in treating elderly with depression?
because of they have active metabolites and many S.E(Cardiac, CNS stimu, agranulo)

Switch to SSRI
Which TCAs are the most activating?
Second:
Nortriptylline
Desipramine
Protriptyline
which antidepressants lower seizure threshold?
All but mostly:

Maprotyline
Amaxopine
Clomipramine
What are the doses for the 2 & 3rd amines (TCA)
25mg/daily

except for vivactil: 15mg
Which TCAs are the most Anticholinergic?
Amitriptyline
Clomipramine