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39 Cards in this Set
- Front
- Back
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Which drug has NMDA receptor blocker and weak carbonic anhydrous inhibition?
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Toprimate(topromax)
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which AEDs cause aplastic anemia?
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Carbamazepine
Felbamate |
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which AED is not effective with absence seizures?
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Phenytoin is not effective
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What is the NTW for:
Phenytoin Phenobarb Valproic Acid Carbamazepine Gabapentin Lithium |
Phenytoin 10-20 mcg/ml
Phenobarb 10-40 mcg/ml Valproic Acid 50-150 mcg/ml Carbamazepine 4-14 Gabapentin 4-16 Lithium 0.8-1.2 meq/L |
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Which Antidepressive drug works on Serotonin and Norepi?
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Venlafaxine(effexor)-causes HTN
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Which drugs increase lithium?
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Theophyline
Thiazides ACEI NSAIDS |
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which drugs decrease levels of carbamazepine?
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Felbamate
Phenytoin Phenobarb |
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Which drugs decrease levels of phenytoin?
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Valproic Acid
Carbamazepine |
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Which drugs increase levels of phenytoin?
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Felbamate
Methsuximide Phenobarb (can inc or decrease) |
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which drugs decrease levels of valproic acid?
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Carbamazepine
Lamotrigine Phenobarb Primidone Phenytoin |
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What's the thyroid DOC in pregnancy? Dose?
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PTU: 75mg QID initial then
100mg/day in divided doses |
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what are the Cardiac S.E of TCAs?
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CHF
Heart block Hypotension Prolong QT Tachy |
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which drugs cause Agranulocytosis?
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Clozapine-atypical antipsych
Methimazole PTU TCAs |
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what are the S.E of Oxcarbamazepine?
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Hyponatremia
Blood dyscrasias |
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Treatment for BZD OD
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Flumazenil
0.5mg IV once |
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what advantages does Fosphenytoin have over phenytoin
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IM or IV dosing
Phlebitis is minimized Faster infusion Can mix in D5 or NS |
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What are the S.E of BZDs
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Sedation
Euphoria Addiction Cognitive impairment(confusion,memory) Ataxia Withdrawal symptoms |
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Which 2nd Gen. AEDs are renally eliminated
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Gabapentin
Topromax |
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what are the side effects of topromax
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paresthesias
psychomotor slowing hyperthermia renal stones metabolic acidosis |
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this drug modulates release of excitatory NTs(glutamate, substance P, Noradrenaline)
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Pregabalin (lyrica)
Unique: site of action is in brain and spinal cord S.E: dizziness and somnolescence |
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Which Atypicals are rapid acting? IM or IV?
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Zyprexa
Abilify Geodone-monitor EKG(QT) Risperdal(tablet form) |
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Tx for bipolar (euphoric/hypomanic/mania)
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Lithium 400mg tid
Zyprexa 5mg/day |
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Tx for agitation
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Haldol and Ativan
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what is the best drug to control schizophrenia?
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clozapine (must have weekly CBC); due to agranulocytosis
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If you prescribe Haldol long term what should you also prescribe?
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Cogentin to counteract the high EPS symptoms
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Name some S.E of typical antipsychotics
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Tardive dyskenisias
Tremors Restlessness Treat with ACHs(benadryl) |
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What is the treatment for Neuroleptic malignant syndrome?
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Dantrolene
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what is the advantage of Atypicals?
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< EPS
Block serotonin receptors |
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what is the clinical presentation of Addison's?
How do you treat? |
Hypoglycemic
Hyperkalemia Hyponatremia (<135) Dehydration Fludrocortisone: 0.05mg/daily Hydrocortisone: 40mg AM/20mg PM |
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How do you treat Graves?
what do you monitor? |
Methimazole 30mg/daily initial
5mg/daily maintenance Monitor: LFT, CBC, GI |
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pregnant woman with hyperthyroidism, how do you treat?
What do you monitor? |
PTU
75mg QID initial 100mg/day in divided doses monitor: LFT, CBC, GI sx |
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Which typical antipsychs have the highest EPS Sx
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Haldol
Prolixin Treat with Benadryl or Cogentin |
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Which TCAs have active metabolites?
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Primary:
Amoxapine Sencondary: Nortriptylline Desipramine Tertiary: Doxepin Imipramine Amitriptyline |
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what can happen if you administer an SSRI or TCA with a MAOI?
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potential fatal reaction; you need a 2 wk washout period with MAOIs
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Why are TCAs not the DOC in treating elderly with depression?
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because of they have active metabolites and many S.E(Cardiac, CNS stimu, agranulo)
Switch to SSRI |
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Which TCAs are the most activating?
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Second:
Nortriptylline Desipramine Protriptyline |
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which antidepressants lower seizure threshold?
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All but mostly:
Maprotyline Amaxopine Clomipramine |
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What are the doses for the 2 & 3rd amines (TCA)
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25mg/daily
except for vivactil: 15mg |
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Which TCAs are the most Anticholinergic?
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Amitriptyline
Clomipramine |
