Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
35 Cards in this Set
- Front
- Back
|
Florosemide
|
Loop Diuretic
-BP regulation -CHF dec. blood volume use at signs of pulmonary edema |
|
|
Hydrocholorthiazide
|
distal tubule Diuretic
-BP regulation -CHF dec. blood volume use at signs of pulmonary edema |
|
|
Spiranolactone
|
K+ sparing Diuretic
-BP regulation -CHF (used in combo with ACE inhibitor (Captopril) to relax arterial SM, dec aldosterone, Dialate veins, reduce hypertrophic changes in heart |
|
|
Propranolol
|
non selective B blocker
-BP regulation -Classic Angina Pectoris (can be given to counteract tachycardia from organic nitrates) |
|
|
Atenolol
|
B1 selective antagonist
-BP -Classic Angina Pectoris (can be given to counteract tachycardia from organic nitrates) |
|
|
Prazosin
|
a1 antagonist
-BP |
|
|
Hydralozine
|
oral vasodialtor
-BP -opens K+ channels hyper polarizing the cell, and inhibiting Ca++ entry = SM relaxation |
|
|
Verpamil
|
cardio active Ca++ channel blocker
-BP -Angina Pectoris (1st choice variant; classic monotherapy if all nitro and B blockers dont work) Block Ca++ channels in SM and cardiac Muscle = dec. O2 demand of heart, and relaxation of coronary vessels |
|
|
amoldipine
|
Non cardioactive CCB
-BP (A.F.I.N. long->short) -Angina Pectoris (Long acting in combo with B blocker if nitro and b blockers dont work) |
|
|
Sodium Nitro Prusside
|
IV nitrate used in emergency situations (Hypertensive)
|
|
|
Nitroglycerin
|
parenteral (transdermal, sublengual) admin
-Angina Pectoris to stop reflex tachycardia may be admin-ed with B blocker GTP->cGMP = open K+ |
|
|
Isosorbide Mono/di nitrate
|
organic nitrate orally admin
-Angina Pectoris to stop reflex tachycardia may be admin-ed with B blocker GTP->cGMP = open K+ |
|
|
Captopril
|
ACE inhibitor
-CHF -BP - ATI --X--> ATII (in lungs) dec. AT1 R activity = (used for CHF in combo with spiranolactone) --dec aldosterone --dec vasodialation --dec. hypertophic changes in heart --dialate veins TERATOGENIC* |
|
|
Aliskiren
|
Renin Inhibitor
-BP |
|
|
Losartan
|
A.R.B.
competitive antagonist at AT1 R -BP TERATOGENIC* |
|
|
Aspirin
|
Anti platelet
Inhibit COX1 "TXA2" (small doses) >375 MAX, 160 during/after, 75-150 before -Anti clotting -unstableAngina Pectoris |
|
|
Clopidigrel
|
ADP R Blocker (P24 12)
prodrug-modified by CYP450 antagonist at P24 on platelet = no platelets bind -clotting -unstable Angina Pectoris |
|
|
Tirofiban
|
GPIIa-IIIb antagonist
Blocks platelet platelet interaction (ADP binds to reveal GPIIA-IIIb) Used in PCI's -clotting -unstable Angina Pectoris |
|
|
Alteplase
|
=t-PA
Fibrinolytic -Clotting -Angina Pectoris, Acute MI |
|
|
streptokinase
|
like t-PA
Fibrinolytic -Clotting -Angina Pectoris, Acute MI |
|
|
Enoxaparin
|
Heparin
parenterally stimulate Antithrombin III low molecular weight TERATOGENIC |
|
|
nonfractionated Heparin
|
mixed high and low MW heparins
parenterally stimulate Antithrombin III TERATOGENIC |
|
|
Hirudin
|
Direct Thrombin inhibitor
derived from leaches TERATOGENIC |
|
|
Warfarin
|
Inactivates VKORC
TERATOGENIC takes time for effect pharmacogenetics... |
|
|
Dobutamine
|
B1 agonist
acute heart failure inc. CO |
|
|
Milrinone
|
PDE3 inhibitor
dec cAMP degradation to AMP inc cAMP=contractions -acute heart failure |
|
|
Atropine
|
muscarinic antagonist
dec. parasympathetic effect on heart -acute heart failure |
|
|
Digoxin
|
-CHF
inc. quality of life but inc. sudden death-arrhythmias -Margin of safety = LOW -blocks Na+K+ pump by competitively binding to K+ site (drugs that alter K+ level alter Digoxin efficacy) |
|
|
Niacin
|
Hypertriglyceridemia
dec. VLDL production inc. Lipoprotein lipase NET dec. LDL, inc. HDL |
|
|
Gemfibrizil
|
Hypertrigyceridemia
dec. VLDL production inc. Lipoprotein lipase NO NET change LDL or HDL |
|
|
Colestipol/cholestyramine
|
inhibit Bile acid reabsorption
LDL used to make Bile |
|
|
Statins (in general)
|
PSAR low-->high efficacy at safe dose
pravastatin, simvastatin, atorvastatin, rosuvastatin *TERATOGEN |
|
|
Atorvastatin/Rosuvastatin
|
high efficacy statin
45-60% reduction in LDL *Teratogen |
|
|
Ezetimibe
|
"Zetia"
Blocks triglyceride absorbtion from digestive tract GI SE |
|
|
Vytorin
|
Ezetimibe + atorvastatin (medium efficacy statin)
*no decrease in plaque compared to statins alone |
