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23 Cards in this Set
- Front
- Back
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2 insulins that eliminated allergic rxns?
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purified pork insulin
recominant human insulin |
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Insulin molecule has intrastrand____
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disulfide bonds
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Regular insulin
onset _____ peak action _____hrs duration ____hrs |
30-60 min
2-3 hrs 8-10 hrs |
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NPH insulin
gives ___ action than regular onset ___ peak action ____hrs duration _____hrs |
longer
2-4 hrs onset 4-10 hr peak 12-18 duration |
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Zinc insulin
give s____action than regular onset duration ____ peak action ____ |
2-4 hour onset (LONGER)
12-20 hour duration 4-12 hour peak |
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Extended zinc iunsulin
gives ____action than regular onset ____ peak _____ duration_____ |
LONGEST
onset 6-10 peak 10-16 duration 18-24 |
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4 types of insuloin preps
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regular
NPH zinc extended zinc |
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Human type insulin vs. pork
HUman is of ____origin its structure is ______ it contains no____which is advantageous because _____ |
recombinant DNA
identical to the human pancrease insulin animal sources no allergic rxn to animal |
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All of the preparations of insulin cause _____ in some way. This is because as ____valiues approached normal, it kept going to ______. So, it is best to use a ______prep.
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hypoglycemia
glycosylated Hgb further reduce blood sugar NPH+Regular split mix(70/30) |
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3 analogues of insulin?
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lispro
aspart glargine |
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Lispro is a _____
its structure is a substition of ____normally at ____ for _____normally at _____. |
insulin analog
Lysine B29 proline B28 |
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aspart is a______
its structure is a substituion of _____normally at _____for ____. |
proline normally at B28 replaced by (-)aspartic acid
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Glargine is a ______
its structure is ____for ____at ____and ____added at ____. |
insulin analog
glycine for aspargine at A21 2 argine added at B30 |
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which insulin analog is LONG acting, slow onset?
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glargine
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which insulin analog is fast acting, like prandial insulin?
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lispro and aspart
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Using 1 analog in diabetics is often to tx Type ____, and it mimics _____.
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1
endogenous insulin |
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Using combo of analog and ____ is to tx Type ____, and helps to ____.
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oral drug
2 enhance oral drug effectiveness |
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What is the most common type of insulin to treat diabetics?
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Novolog mix 70/30
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what is the advantage of onset/duration of novolog 70/30?
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onset rapid, duration 12-18 hrs
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Detemir's chemical difference?
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no threonine at B30
add 14 C FA chain at b29 |
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gluisine chemical difference?
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replace @ b3/b29
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gluisine action (onset) and who it treats?
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rapd 2-4 hrs
type 1 and 2 |
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detemir action,, who it treats?
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longer lasting
12-18 hrs @ low dose 24 hrs @ high dose type 1 and 2 |
