Pharm Test 2 Uterine Drugs

Front 1

Oxytocin

1)MOA
2)CU

b)given in pharm doses...
c)given in second half of pregnancy

Back 1

1)activates Gq proteins ->inc phospholipase C and inc Ca2+
Also, Inc local prostaglandin synthesis

2)DOC Induce Labor
Postpartum Hemorrhage (maintains uterine contraction to stop hemorrhage)
Induce Abortion (High Dose)
Oxytocin Challenge Test (abnormal response indicates fetal hypoxia)

b)induces uterine contractions and maintain labor
c)at this time, uterine smooth muscle inc expression of oxytocin receptors and becomes extra sensitve to the stim action of oxytocin

Front 2

Oxytocin

3)AE
4)Contra
5)How Do you give?

Back 2

3)Fetal Distress (d/t excessive stim of uterine contractions)
Inc Vasopressor Receptors ->inc fluid retention -> hyponatremia, heart failure, seizures, and death

4)Fetal DistressPrematurity, Abnormal Fetus Pressure, Cephalopelvic disproportion

5)IV at constant rate (bolus injections can cause HYPOtension

Front 3

Ergonovine / Methylergonovine

1)MOA
2)CU
3)AE
4)Prolonged Use can cause...

Back 3

Oxytocic (Uterine Stimulant)

1)Alpha Adrenergic/Serotonin Agonist

2)Postpartum Hemorrhage (if oxytocin is ineffective

3)HTN, headaches, seizures, nausea, vomit, chest pain

4)Can cause poisoning in infant via breast milk

Front 4

Ergonovine / Methylergonovine

5)Contra

6)Low Doses Causes

7)High Doses Causes

Back 4

5)Angina, MI, Pregnant, TIAs

6)Rhythmic contracts, uterus relaxation

7)Power and Prolonged Contractions

Front 5

Dinoprostone

1)MOA
2)CU

Back 5

Oxytocic (Uterine Stimulant)

1)PGE2 (uterine stimulant)

2)Abortion (2nd trimester)
Evacuation of uterine contents
Hydatidiform Mole
Ripening of uterus for labor

Front 6

Carboprost

1)MOA
2)CU

Back 6

Oxytocic (Uterine Stimulant)

1)PGF2 alpha (synthetic analog)

2)Abortion (2nd Trimester)
Postpartum hemorrhage (use if oxytocin and ergonovine is ineffective)

Front 7

Tromethamine

1)MOA
2)CU

Back 7

Oxytocic (Uterine Stimulant)

1)PGF2 alpha (synthetic analog)

2)Abortion (2nd Trimester)
Postpartum hemorrhage (use if oxytocin and ergonovine is ineffective)

Front 8

Misoprostol

1)MOA
2)CU

Back 8

Oxytocic (Uterine Stimulant)

1)PGE1

2)Used mainly for NSAID induced gastric ulcers (not aproved for obstetrics)
Cervical Ripening
Labor Induction
Postpartum Hemorrhage

Front 9

Terbutaline

1)MOA
2)CU
3)AE

Back 9

Tocolytic (Uterine Relaxant)

1) B2 agonist -> SM relaxation
(inc cAMP->inc PKA-> SmMLCK phosphorylation ->SM relaxation)

2)Relax uterine Smooth Muscle

3)SERIOUS; Pulm edema, Arrhythmias, MIs, Maternal Death

Front 10

Mg Sulfate

1)MOA
2)CU
3)AE

Back 10

Tocolytic (Uterine Relaxant)

1)dec Ca -> dec Action Potential -> uncouples excitation

2)relaxes uterine smooth muscle

3)Life threatening RESP DISTRESS

Front 11

Indomethacin

1)MOA
2)CU
3)AE

Back 11

Tocolytic (Uterine Relaxant)

1)NSAID

2)Delays Preterm Labor (by dec prostoglandins)

3)prematurely closes fetal ductus arteriosus

Front 12

Nifedipine

1)MOA
2)CU

Back 12

Tocolytic (Uterine Relaxant)

1)Ca Blocker (in myometrial cells)

2)Inhibits contractility

Front 13

Atosiban

1)MOA
2)CU

Back 13

Tocolytic (Uterine Relaxant)

1)Antagonizes oxytocin receptors

2)Delays Preterm Labor
Decreases and Stops Contractions

Front 14

Why would you give a tocolytic?

Back 14

Prolonged intrauterine life would benefit fetus
Allow Treatment with other Drugs
Temporary Uterine Relaxation