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35 Cards in this Set
- Front
- Back
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1)What are infections with helminths?
2)What are nematodes? 3)What are trematodes? 4)What are cestodes? |
1)Infections by worms (Nematodes, Trematodes, Cestodes)
2)Roundworms that have complete digestive system (mouth to anus). Infect intestine, blood, and tissue 3)Flatworms that are characterized by what they infect: Liver, intestine, blood Flukes 4)Flatworms with segmented body; Attach to host intestine, and lack mouth and digestive system |
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1)What are the 3 Benzimidazoles?
2)Who cant u give these drugs too? 3)How cant you take these drugs? 4)Moxt toxic of these? |
1)Albendazole, Mebendazole, Thiabendazole
2)Pregnancy and kids under 2 3)Orally (because very difficult to absorb) (except thiabendazole) 4)Thiabendazole |
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1)What is Albendazole?
2)How does it do it? 3)Long Term AE 4)Main problem with albendazole |
1)treats cestode infections
2)inhibits microtubule synthesis and dec glucose uptake 3)Hepatotoxicity , Pancytopenia 4)have a dead parasite, and get bad inflam response to it ->vomit, hyperthermia, convulsions |
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DOC Whipworm
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1)Mebendazole
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DOC Pin Worm
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Mebendazole
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DOC Hook Worm
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Mebendazole
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DOC Roundworm
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Mebendazole
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Mebendazole
1)What is it? 2)First pass metabolism too what? |
1)inhibits microtubule synthesis and dec glucose uptake; and parasites expelled in feces
2)Inactive compound (albendazole to an active compound) |
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Thiabendazole
1)What is it? |
1)Treats styonglyloides stercoralis (threadworm)
by affecting microtubule aggregation (most toxic of bendazole) |
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DOC for Onchocerciasis
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1)ivermectin
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ivermectin
1)What is it? 2)What dont you give it with? 3)Contra in what? |
1)Gaba agonist leading to inc Cl- and hyperporalization and paralysis of worm (not cidal, immune system finishes job)
2)Barbituates, BZDs, d/t additive effect 3)Pregnancy, Meningitis (because get leaky BBB) |
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Piperazine
1)What is it 2)Contra |
alternative treatment for Ascariasis
works as GABA agonist 2)patients with seizure disorders |
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Pyrantel Pamoate
1)What is it? |
1)depolarizing neuromuscular blocker (but not well absorbed)
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DOC lymphatic filariasis
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Diethylcarbamazine
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DOC loiasis
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diethylcarbamazine
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DOC tropical eosinophilia
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Diethylcarbamazine
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Diethylcarbamazine
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immobilizes microfilariae so immune system can kill them
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Doxycycline
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tetracycline against Wuchereria bancrofti (directly kills it)
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DOC Shistosomiasis
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Praziquantel
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DOC Trematodes
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Praziquantel
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DOC Cestodes
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Praziquantel
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DOC Cysticercosis
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Albendazole
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Praziquantel
1)What is it? 2)Contra? |
inc perm of cell membrane to calcium causing permanent contraction and paralysis of parasite (has short half life)
2)Preganancy Ocular Cysticercosis (can damage eye) |
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DOC Fasciolosis (Sheep Liver Fluke)
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Bithionol
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Bithionol
1)how does it work? |
inhibits helminth electron transport chain
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Niclosamide
1)What is it? 2)What to give with it? 3)What cant you take within 1 day |
1)second line treatment for cestode infections
2)need to give laxative first (to get rid of dead segments) 3)Alcohol |
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DOC Cutaneous larva migrans
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Albendazole or Ivermectin
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DOC Echinococcosis
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Albendazole
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DOC Taenia Solium/Saginatum
(Pork/Beef tapeworm) |
Praziquantel or Niclosamide
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DOC Trypanosoma cruizi
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Nifurtimox
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DOC Toxoplasmosis
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Pyrimethamine and Clindamycin
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DOC African Sleeping Sicknes
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Melarsoprol
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DOC Leishmaniasis
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Sodium Stibogluconate
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DOC Trypanosomiasis
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Suramin
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DOC PCP (Pneumocystic jiroveci)
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Trimethoprim and sulfamethoxazole *************************************************************KNOW IT
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