Pharm Test 2 Antiprotozoals: Antiamebics

Front 1

1)What is amibiasis?

2)All the drugs in this section can not be used when?

3)E. histolytica exists in which forms

Back 1

1)intestinal tract infection by E. histolytica (amebic dysentery)

2)In pregnancy, because too toxic

3)Cysts (can survive outside body)
Trophozites (cant survive outside body) (requires a host to be outside body)

Front 2

1)Lifecycle of E. histolytica?

2)E. histolytica requires what to survive?

3)Drugs act on what?

Back 2

1)Ingest cyst -> intestinal lumen -> trophozites liberated and multiply -> invade and ulcerate LI mucosa -> rectum -> back to cyst form -> feces

2)Intestinal bacteria to feed on (thus cant survive outside of body)

3)Amebas in lumen, system, or mixed (if systemic, need to give systemic drug and lumen drug to make sure rid of all the amebas)

Front 3

1)What is the mixed amebicide of choice

2)This drug also used in combo with other drugs to treat what?

Back 3

1) Metronidazole (often used with lumenal amebicide to make sure everything destroyed)

2)H. pylori

Front 4

1)DOC Giardia?

Back 4

1)Metronidazole

Front 5

1)DOC Trichomonas

Back 5

1)Metronidazole

Front 6

Metronidazole

1)MOA

2)AE

Back 6

1)has a nitro group that is Reduced, forming a cytotoxic compound that causes cell death (CIDAL)

2)Metallic Taste
Dark Colored Urine
Disulfiram like reaction with alcohol

Front 7

Tinidazole

1)What is it?

Back 7

1)2nd gen of metronidazole, and is better tolerated (but cost restricts use of drug)

Front 8

1)What are the 3 luminal antiamebics?

Back 8

1)Diloxanide furoate, Iodoquinol, Paromomycin

Front 9

iodoquinol

1)What is it?

Back 9

used for luminal trophozites and cysts

should not be used long term

Front 10

Diloxanide Furoate

1)What is it?

Back 10

1)DOC for treatment of luminal, ASYMPTOMATIC amebiasis

converted to active form in gut

Front 11

Paromomycin

1)What is it?

Back 11

1)an aminoglycoside (targets 30S) against luminal E. histolytica and tapeworm

(is also CONC dependent -> only need to give once daily)

Front 12

1)What are the 3 systemic antiamebics?

2)Are used for?

Back 12

1)Chloroquine, Emetine, Dehydroemetine

2)to treat liver abscesses or intestinal wall infections

Front 13

Chloroquine

1)What is it?

Back 13

1)systemic amebic;

use with metronidazole and diloxanide furoate for the amebic liver abscesses

Front 14

Emetine and Dehydroemetine

1)What are they?

2)do you have to give them often?

Back 14

1)BACKUP systemic drugs for intestinal hepatic amebiasis (with luminal agent)

2)no, long half life

Front 15

1)DOC for asymptomatic amebic infection?

2)DOC for mild intestinal infection

3)DOC for severe intestinal infection

Back 15

1)Diloxanide furoate

2)Metronidazole and luminal agent

3)Metronidazole or Tinidazole; and luminal agent

Front 16

4)DOC for hepatic abscess and extraintestinal amebic infection?

5)Luminal agent of choice for amebiasis?

Back 16

4)Metronidazole or Tinidazole; and luminal agent

5)Diloxanide furoate