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74 Cards in this Set
- Front
- Back
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Epinephrine
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alpha > beta 1 or beta 2
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Norepinephrine
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potent alpha 1 and Beta 2
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Dopamine
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dopamine 1 & 2, beta 1, alpha
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Endogenous catecholamines
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epi, norepi, dopamine
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Synthetic catecholamines
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isoproterenol
dobutamine fenoldopam dopexamine |
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isoproterenol
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beta 1 & 2
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fenoldopam
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dopamine 1
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dopexamine
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dopamine and beta 2
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Synthetic non-catecholamines
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ephedrine
mephentermine amphetamine phenylephrine methoxamine |
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Ephredrine
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indirect alpha & beta 1, Direct Beta 2 (20-30)
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mephentermine
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indirect alpha and beta
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amphetamine
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alpha and beta
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phenylephrine
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direct alpha 1
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methoxamine
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direct alpha 1
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Selective beta 2 agonists
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albuterol
metaproterenol bitolterol isoetharine terbutaline ritodrine |
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alpha 2 agonists
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clonidine 200:1
dexedetomidine 1600:1 |
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anticholinesterase (cholingeric agonist)
N2 receptors |
carbamates
quaternary ammonium alchols organophosphates |
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Carbonates
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neostigmine - QA
pyridostigmine - QA physiostigmine - TA |
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Quaternary ammonium alcohols
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edrophonium - QA
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organophosphates
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echothiophate - TA
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Anticholinergics (antimuscarinic)
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Atropine - TA
Scoplamine - potent antisialogogue and CNS effects Glycopyrrolate - QA |
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Sympatholytic alpha antagonists
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Phentolamine - regitine
prazosin - minipress terazosin - Hystin Doxazosine - cardura Phenoxybenzamine - dibrazyline yohimbine |
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Phentolamine (Regitine)
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non-selective, blocks alpha 1 > alpha2
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Prazosin (Minipress)
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selective alpha 1 blocker
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terazosin (Hytrin)
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selective alpha 1
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Doxazosine (cardura)
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selective alpha 1
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phenoxybenzamine (dibeazyline)
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irreversible binds alpha 1 > alpha 2 no antagonism
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Yohimbine
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selective presynaptic alpha 2 blocker
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Sympatholytic Beta Antagonist
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non selective (blocks beta 1 & beta 2
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sympatholytic beta antagonist
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propranolol (inderal)
Nadolol (corgard) Timolol (timoptic) Sotalol (betapace) |
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beta antagonist - cardioselective - blocks beta 1
large doses non-selective |
metoprolol
atenolol betaxolol esmolol |
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Esmolol metabolism
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hyrdrolysis by RBC esteraces
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alpha & beta antagonist
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Labetalol (normadyne)
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labetalol
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selective alpha 1 & nonselective beta
Beta : alpha blocking - 3:1 oral 7:1 IV |
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angiotensin - converting enzyme inhibitors
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for dec CO and inc filling pressures
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ACE inhibitors
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captopril
enalapril lisinopril ramipril |
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angiotensin II receptor blocker
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inhibits binding of angiotensin II to ATI receptors therefore no vasoconstriction or aldosterone secretion so no H2O and Na+ retention
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angiotensin II receptor blocker (AT1)
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Losartan (Cozaar) 2-3 fold increase in renin activity (H2O retention)
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Vasodilating drugs - arteriolar dilator leads to forward flow for decreased LV output (CO)
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hydralazine (apresoline) selectively relaxing arterial smooth muscle
Minoxidil (rogaine) |
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Nitric Oxide Activators - venous dliator lead to increased filling pressure (preload)
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nitroglycerin
Isosorbide- oral nitrate Inomax Nitroprusside |
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Nitroglycerin
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organic nitrate - incr. doses- relaxation of arterial vascular
acts on venous capacitance vessels and large coronary arteries |
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Nitroprusside
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direct acting non selective peripheral vasodilator
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Papeverine
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vasodilator - inhibit phosphodiesterase
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Adenosine
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endogenous potent coronary artery vasodilator
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dipyridamole
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vasodilator - selective adenosine uptate inhibitor
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Calcium channel blockers
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dec Ca+ leads to vasodilation
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Diuretics
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decreased volume, decreased preload, decreased BP
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Alpha 1
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postsynaptic
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agonist
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vasoconstriction
mydriasis relaxation GI tract contraction GI sphincters contraction bladder sphincter |
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alpha 1 antagonist
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vasodilation
miosis contraction of GI tract Relaxation of GI sphincters Relaxation bladder sphincter |
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alpha 2 (postsynaptic) antagonist
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allows NE release
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Alpha 2 agonist
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(presynaptic)
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Alpha 2 (presynaptic) agonist
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inhibit NE release
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Alpha 2 (presynaptic) antagonist
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allows NE release
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Alpha 2
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(post synaptic)
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Alpha 2 (post synaptic) agonist
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platelet aggregation
hyperpolarize CNS (sedation) |
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Alpha 2 (post synpatic) antagonist
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hypopolarize CNS
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Beta 1
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Post synaptic
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beta 1 post synaptic agonist
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incr. conduction (dromotrophy)
incr. automaticity incr. contractility (inotrophy) incr. HR (chronotrophy) |
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Beta 1 post synaptice antagonist
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decr. conduction
decr. automaticity decr contractility decreased HR |
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beta 2
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postsynaptic
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Beta 2 postsynaptic agonist
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vasodilation
bronchodilation gi relaxation bladder relaxation glycogenolysis lipolysis (beta 3) |
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Beta 2 postsynaptic antagonist
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vasoconstriction
bronchoconstriction ci contraction uterine contraction bladder contraction decr. amt of glucose (decr glycogenolysis) |
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Dopamine 1
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post synaptic - renal, mesentery,
coronary, cerebral |
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Dopamine 1 (post synaptic) agonist
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vasodilation
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Dopamine 1 (post synaptic) antagonist
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vasoconstriction
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Dopamine 2
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presynaptic
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dopamine 2 presynaptic agonist
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inhibit NE release
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Dopamine 2 presynaptic antagonist
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allows NE release
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Cholinergic receptors
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muscarinic
nicotinic 1 nicotinic 2 |
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Cholinergic muscarinic agonist -
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PNS response
miosis decr. HR decr. contractility vasodilation bronchocontriction incr. motility GI sphincter relaxation bladder contraction bladder sphincter relaxation incr. gland secretion |
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Cholinergic muscarinic agonist
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mydiasis
incr. HR incr. contractility vasoconstriction bronchodilation decr motility GI sphincter contraction bladder relaxation bladder sphincter contraction decr. gland secretion |
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nicotinic 1
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autonomic ganglia
blocked by ganglionic blocking agent |
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Nicotinic 2
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NMJ
blocked by NMB |
