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8 Cards in this Set
- Front
- Back
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4 ways drugs are administered
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oral
IV IM Subcutaneous |
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Drugs can get through membranes via ___A____which is moving through concentration gradient. This can be helped by the addition of ___B___. Another way to move through membranes is __C__ which is done by salts, moving through ___D___. A 3rd way is how penicillin is transported which is____E___.
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A - simple diffusion
B - lipophilic functional groups C - filtration D - channels E - active transport |
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THe efflux drug transporter system is seen in ___A___(2 organs). through the transporter __B___. this is seen in resistance to certain chemotherapies,
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A - brain/intestine
B - P-glycoprotein |
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The "first pass effect" is a way that drugs are ___A___ed. It occurs in the ___B___. In this effect, a large amount of the drug is____ to ____ via_____, which is in the _____
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metabolized
liver metabolized to inactive metabolites p450 endoplasmic reticulum |
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4 places drug goes after oral absorption into the liver
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inf. vena cava (general circ)
Bile duct lower intestine reabs into portal vein |
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what advantage, time wise, does the IV route have?
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bypasses the liver, skips "first pass" metabolism
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When drugs are transported by blood, it does so via ____'s proteins ____and ____
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Plasma
albumin glycoproteins |
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6 routes of drug excretion
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Renal
Bile/Feces Milk Sweat Lungs Saliva |
