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13 Cards in this Set
- Front
- Back
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Define the biological 1/2 life of a drug?
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time it takes for 1/2 the peak blood level to leave the blood
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define when (graphically) the peak blood level occurs
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at the beginning of 2nd elimination phase
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Define 1st order elimination
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rate of drug elimination is directly proportional to concentration, and follows 1st order kinetics
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Which is 1st order elimination of a drug?
A. drug's 1/2 life is 2 hours B. Drugs elimination occurs in 4 half lifes exactly C. rate of drug eliminatin is directly proportional to concentration, follows 1st order kinetics |
C
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What is the Kel of a drug?
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elimination rate (% eliminated) of any drug in 1 hour
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Which is Kel of a drug?
A. Time it takes for a drug to be completely eliminated B. The rate of elimination from the blood in 1 hour C. The rate for 1/2 to be eliminated from the blood |
B
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How is Kel obtained from a graph?
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slope of the 2nd elimination phase
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How does Kel relate to T 1/2?
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.693/T1/2
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If a drug is given repeatedly, the rate of drug administration counterbalances ____A____ and results in ____B____
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A - elimination
B - accumulation |
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Since any drug is eliminated in about ___A___ 1/2 times, any drug wil acquire maximal accumulation w/in ____B____ 1/2 times using a dosing schedlue of___C___
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A - 4
B - 4 C - every T 1/2 |
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Define optimal therapeutic level
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the level of a drug in blood needed to maintain therapeutic effect WITHOUT toxicities and no reduction in effect
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Is Optimal therapeutic level the T 1/2?
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NOT ALWAYS
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From the graph, what is
T 1/2? Peak blood level? Kel? |
Peak blood level is 8
T 1/2 is 3.5-.5 = 3 hours Kel = .693/3 = .231 |
