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5 Cards in this Set
- Front
- Back
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Ach (Miochol) – Esters of Choline
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Direct Acting Cholinergic Agonists:
Does NOT cross BBB Miosis in eye Accom. for NEAR vision 5-20 secs (Metabolized by Ach-esterase) |
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Methacholine (Provocholine) – Esters of Choline
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Direct Acting Cholinergic Agonists:
Does NOT cross BBB No affinity for Nicotinic Receptor Used to DX bronchial hyperactivity & asthma Given by inhalation 3x RESISTANT to Ach-esterase |
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Bethanechol (Urecholine) – Esters of Choline
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Direct Acting Cholinergic Agonists:
Does NOT cross BBB PURE Muscarinic agonist ↑ tone & mobility of intestines contract BLADDER WALL (urination) in postpartum or postop urinary retention Single admin can last up to 1 hour RESISTANT to Ach-esterase SIDE EFFECTS: sweating, salivation, flushing, ↑BP, nausea, ab pain, diarrhea, bronchospasm CONTRAINDICATIONS: asthma, hyperthyroidism, coronary insuff., acid-pepsin dz |
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Pilocarpine (Isopto Carpine) -- Alkaloid
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Direct Acting Cholinergic Agonists:
Crosses BBB Topical admin—Cornea Rapid MIOSIS of eye Accom. for NEAR vision Drug of choice in the emergency ↓ IOP of both narrow- and open-angle glaucoma (standard for latter) Oral admin Tx XEROSTOMIA assoc. w/head & neck radiation tx Enhance salivation (ease of swallowing & hydrate oral cavity) SIDE EFFECTS: profuse SWEATING!! Potent SWEATING & SALIVATION!! |
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Nicotine -- Alkaloid
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Direct Acting Cholinergic Agonists:
Ganglionic stimulant & blocker Acutely, ↑HR & BP (due to activation of Adrenal Medulla) ↑ tone and motility in GI tract (stimulates PNS) SIDE EFFECTS: can cause ↑BP and cardiac arrythmias, a poison |
