Pharm - Sulfonamides, Trimethoprim And Fluoroquinolones

Front 1

T or F about sulfonamides? cross-allergenicity with penicillins

Back 1

FALSE

Front 2

T or F about sulfonamides? crystalluria with high urinary pH

Back 2

false; occurs at low pH

Front 3

T or F about sulfonamides? basal ganglia dysfunction in newborns if used in 3rd trimester

Back 3

TRUE

Front 4

T or F about sulfonamides? bactericidal

Back 4

false; bacteriostatic

Front 5

T or F about sulfonamides? inhibit bacterial dihydrofolate reductase

Back 5

false; inhibits dihydropteroate synthase

Front 6

TMP-SMX is effective against what opportunistic infection of AIDS?

Back 6

Toxoplasmosis (protozoa)

Front 7

Tx of pathogenic Gram neg bacillus causing diarrhea after vacation

Back 7

Levofloxacin

Front 8

T or F about sulfonamides? resistant strains have decreased intracell accumulation of the drug

Back 8

TRUE

Front 9

T or F about sulfonamides? activity against C trachomatis and can be used topically for tx of chlamydial eye infections

Back 9

TRUE

Front 10

T or F about sulfonamides? effective in Rocky Mountain spotted fever in pt allergic to tetracyclines

Back 10

FALSE (should use chloramphenicol

Front 11

T or F about sulfonamides? minimally effective as sole agents in chronic prostatitis

Back 11

TRUE

Front 12

T or F about sulfonamides? resistance can occur in strains because of increased production of PABA

Back 12

TRUE

Front 13

DOC for gonorrhea and chlamydia co-infection

Back 13

ofloxacin

Front 14

T or F about fluoroquinolones? antacids increase BA

Back 14

false; decreases

Front 15

T or F about fluoroquinolones? gonococcal resistance involves change in DNA gyrase

Back 15

TRUE

Front 16

T or F about fluoroquinolones? modification of moxifloxacin dosage is needed if Cr Cl is less than 50

Back 16

false; all others except moxifloxacin are excreted renally, moxifloxacin is excreted via liver

Front 17

T or F about fluoroquinolones? DOC for uncomplicated UTI in 7 yo girl

Back 17

false; causes cartilage damage

Front 18

T or F about fluoroquinolones? contraindicated in hepatic dysfunction

Back 18

FALSE

Front 19

Sulfonamide DOC for UC

Back 19

sulfasalazine

Front 20

T or F about TMP-SMX? alt to ampicillin for listeriosis

Back 20

TRUE

Front 21

T or F about TMP-SMX? tx of CAP

Back 21

false (should use macrolide or doxycycline)

Front 22

T or F about TMP-SMX? tx of Pneumocystis jiroveci pneumonia

Back 22

TRUE

Front 23

T or F about TMP-SMX? fever and pancytopenia occur frequently in AIDS pts

Back 23

TRUE

Front 24

T or F about TMP-SMX? produce a sequential blockade of folic acid synthesis

Back 24

TRUE

Front 25

Most likely SE of sulfonamide

Back 25

skin reactions

Front 26

DOC for nocardiosis and when combined with pyrimethamine is used for P jiroveci prophylaxis?

Back 26

sulfadiazine (and TMP-SMX)

Front 27

T or F about ciprofloxacin? active against MRSA

Back 27

false; about 50% are resistant

Front 28

T or F about ciprofloxacin? clinical antagonism if used with inhibitors of dihydrofolate reductase

Back 28

FALSE

Front 29

T or F about ciprofloxacin? should not be used for first time UTI

Back 29

FALSE

Front 30

T or F about ciprofloxacin? org assoc with middle ear infection are highly resistant

Back 30

FALSE

Front 31

T or F about ciprofloxacin? tendinitis and tendon rupture may occur

Back 31

TRUE

Front 32

supplementary folic acid should be given with this weak base drug to prevent anemia

Back 32

trimethoprim

Front 33

acute hemolysis in those with G6PD may occur with what folate antagonist?

Back 33

sulfonamides

Front 34

2 fluoroquinolones that are 2nd line therapy for gonorrhea

Back 34

ciprofloxacin and ofloxacin

Front 35

3 fluoroquinolones that prolong QTc

Back 35

gemifloxacin, levofloxacin, moxifloxacin

Front 36

Anti-biotic frequently used for chronic UTI prophylaxis

Back 36

sulfamethoxazole/ trimethoprim

Front 37

Anti-microbials that cause hemolysis in G6PD-deficient patients

Back 37

Sulfonamides

Front 38

Reason fluoroquinolones are contraindicated in children and pregnancy

Back 38

Cartilage damage

Front 39

Anemia caused by trimethoprim

Back 39

Megaloblastic anemia

Front 40

MOA of sulfonamides

Back 40

Inhibit dihydropteroate synthase

Front 41

MOA of quinolones

Back 41

Inhibit DNA gyrase

Front 42

MOA of trimethoprim

Back 42

inhibits bacterial dihydrofolate reductase