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19 Cards in this Set
- Front
- Back
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Receptor specificity for all sympathomimetic special agents (cocaine, tyramine, ephedrine, amphetamine, methamphetamine, phenmetrazine, methylphendia, modafinil, pemoline, phenylpropanolamine)?
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indirect
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MOA for cocaine?
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inhibition of neurotransmitter uptake at catecholaminergic synapses
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Kinetics for cocaine?
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readily enters CNS, amphetamine-like effects
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Clinical use for cocaine?
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local reduction of blood flow
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Toxicity for cocaine?
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restlessness, dizziness, tremor, hyperactive reflexes, anxiety, delirium, libido changes, paranoid hallucination, panic states, suicidal tendencies
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MOA for tyramine?
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stimulates release of catecholamines
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Kinetics for tyramine?
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found in food, Beer, beans cheese, meets, wine and yeast. Inactivated by MAO
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Clinical use for tyramine?
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none
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Toxicity for tyramine?
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catecholamine excess especially when taken with MAO inhibitors
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MOA for ephedrine?
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stimulates release of catecholamines and directly activates adrenoreceptors
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Kinetics for ephedrine?
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non-catechol = well absorbed and good CNS penetration. Long duration of action
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Clinical use for ephedrine?
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nasal decongestant, asthma, chronic orthostatic hypotension, long term pressor effects
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Toxicity for ephedrine?
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anorexia, insomnia, hypertension, arrhythmias
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MOA for amphetamine, methamphetamine, phenmetrazine, methylphenidate, modafinil and pemoline?
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stimulates release of catecholamines and blocks reuptake
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Kinetics for amphetamine, methamphetamine, phenmetrazine, methylphenidate, modafinil and pemoline?
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non-catechol = well absorbed and good CNS penetration. Long duration of action
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Clinical use for amphetamine, methamphetamine, phenmetrazine, methylphenidate, modafinil and pemoline?
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anorexiant, ADHD, narcolepsy
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Toxicity foramphetamine, methamphetamine, phenmetrazine, methylphenidate, modafinil and pemoline?
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restlessness, dizziness, tremor, hyperactive reflexes, anxiety, delirium, libido changes, paranoid hallucination, panic states, suicidal tendencies
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MOA for phenylpropanolamine?
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weak sympathomimetic activity
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Clinical use for phenylpropanolamine?
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weight reduction, OTC
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