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9 Cards in this Set
- Front
- Back
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Depolarizing Agent Reacts with the nicotinic receptor to open the ion channel and cause depolarization With prolonged exposure, initial depolarization decreases, repolarization occurs, and is desensitized |
Succinylcholine |
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Non-depolarizing Agent Competes with ACh for the binding site, and enters and blocks the ion channel at high doses Intermediate-acting and highly dependent on liver metabolism |
Vecuronium |
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Non-depolarizing Agent Competes with ACh for the binding site, and enters and blocks the ion channel at high doses Intermediate-acting and highly dependent on liver metabolism |
Rocuronium |
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Non-depolarizing Agent Competes with ACh for the binding site, and enters and blocks the ion channel at high doses Intermediate-acting and metabolite can enter the CNS and cause seizures |
Atracurium |
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Non-depolarizing Agent Competes with ACh for the binding site, and enters and blocks the ion channel at high doses Stereoisomer of atracurium and is less likely to produce toxic metabolites |
Cisatracurium |
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Centrally-acting Spasmolytic Drugs Facilitates the action of GABA to reduce muscle tone and cause sedation at the required dose |
Diazepam |
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Centrally-acting Spasmolytic Drugs Agonist at the GABA-B receptor, resulting in hyperpolarization and reduction of the release of excitatory neurotransmitters in the brain and spinal cord |
Baclofen |
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Centrally-acting Spasmolytic Drugs Alpha-2 agonist, works at the pre-synaptic terminal |
Tizanidine |
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Direct-acting muscle relaxant Reduces skeletal muscle strength by interfering with excitation-contraction coupling in the muscle fibers; prevents the release of calcium by blocking the channel in the sarcoplasmic reticulum |
Dantrolene
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