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72 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Antidotes:
Acetaminophen |
N-acetylcysteine
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Antidotes:
Salicylates |
Alkanize urine, dialysis
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Antidotes:
Anticholinesterases Organophosphates |
Atropine, pralidoxime
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Antidotes:
Antimuscarinic Anticholinergic agents |
Physostigmine salicylate
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Antidotes:
B-blockers |
Glucagon
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Antidotes:
Digitalis (5 things) |
Stop dig
normalize K+ lidocaine Anti-dig Fab fragments Mg++ |
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Antidotes:
Iron |
Deferoxamine
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Antidotes:
Lead (4) |
CaEDTA
dimercaprol succimer penicillamine |
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Antidotes:
Arsenic Mercury Gold |
Dimercaprol (BAL)
Succimer |
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Antidotes:
Copper arsenic gold |
Penicillamine
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Antidotes:
Cyanide (3) |
Nitrite
Hydroxocolbamin Thiosulfate |
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Antidotes:
Methemoglobin |
Methylene blue
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Antidotes:
Carbon Monoxide |
100% O2
hyperbaric O2 |
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Antidotes:
Methanol ethylene glycol |
Ethanol, dialysis, fomepizole
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fomepizole is a competitive inhibitor of alcohol dehydrogenase
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Antidotes:
Opioids |
Naloxone/naltrexone
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Antidotes:
Benzodiazepines |
Flumazenil
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Antidotes:
TCAs |
NaHCO3
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Antidotes:
Heparin |
Protamine
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Antidotes:
Warfarin (2) |
Vitamin K
FFP |
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Antidotes:
tPA Streptokinase |
Aminocaprotic acid
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Lead poisioning in a kid
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Succimer
"sucks" to be a kid who eats lead |
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Lead poisoning in an adult
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EDTA and Dimercaprol
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Signs of lead poisoning
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Lead Lines on gingivae and epiphysis of long bones
Encephalopathy and Erythrocyte basophilic stippling Abdominal colic and sideroblastic Anemia Drops - wrist and foot drop |
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Drug rxn:
Atropine like side effects |
Tricyclics
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Drug rxn:
Cardiac toxicity (2) |
Doxorubicin (adriamycin)
daunorubicin |
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Drug rxn:
Coronary vasospasm |
Cocaine
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Drug rxn:
Cutaneous flushing (4) |
Niacin,
Ca++ Channel blockers adenosine vancomycin |
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Drug rxn:
Torsades des pointes |
Class III (sotalol)
Class IA (quinidine) antiarrhythmics cisapride |
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Drug rxn:
Agranulocytosis (3) |
Clozapine
carbamazepine colchicine |
two antiepileptics
One anti-gout |
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Drug rxn:
Aplastic anemia (3) |
Chloramphenicol
benzene NSAIDs |
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Drug rxn:
Gray Baby syndrome |
Chloramphenicol
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Drug rxn:
Hemolysis in G6PD deficient pts (I Never Prescribe Aspirin If Ibuprofen Suffices) |
Isoniazid (INH)
Nitrofurantoin Primaquine Aspirin Ibuprofen Sulfonamides |
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Drug rxn:
Thrombotic Complications |
OCPs
(e.g., estrogens and progestins) |
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Drug rxn:
Cough |
ACE inhibitors
note: no cough in losartan and AARB |
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Pulmonary fibrosis
(3) |
Bleomycin
AMIODARONE busulfan |
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Drug rxn:
Acute cholestatic hepatitis |
Macrolides
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Drug rxn:
Focal to massive hepatic necrosis 3 drugs 1 mushroom |
Halothane
Valproic acid acetaminophen Amanita phalloides (death cap) |
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Drug rxn:
Hepatitis |
INH
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Drug rxn:
Pseudomembranous colitis (2) |
Clindamycin
Ampicillin |
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Drug rxn:
Adrenocortical insufficiency |
Glucocorticoid withdrawl (HPA suppression)
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Drug rxn:
Gynecomastia (some drugs create awesome knockers) +e |
Spironolactone
Digitalis Cimetidine chronic Alcohol abuse estrogens Ketoconazole |
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Drug rxn:
Hot flashes |
Tamoxifen
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Drug rxn:
Gingival hyperplasia |
Phenytoin
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Drug rxn:
Osteoporosis (2) |
Corticosteroids
Heparin |
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Drug rxn:
Photosensitivity (SAT for a photo) |
Sulfonamides
Amiodarone Tetracycline |
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Drug rxn:
SLE - like syndrome (it's not HIPP to have lupus) |
Hydralazine
INH Procainamide Phenytoin |
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Drug rxn:
Tendonitis, tendon rupture, cartilage damage (kids) |
Fluoroquinolones
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Drug rxn:
Fanconi's syndrome |
Expired tetracycline
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proximal tubule of the kidney doesn't work
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Drug rxn:
Interstitial nephritis |
Methicillin
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Drug rxn:
Hemorrhagic Cystitis (2) |
Cyclophosphamide
Ifosfamide |
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Drug rxn:
Cinchonism What is cinchonism? See hint |
Quinidine
quinine |
tinnitus, headache, deafness, occasionally anaphylactic shock
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Drug rxn:
Diabetes insipidus |
Lithium
demeclocycline |
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Drug rxn:
Seizures |
buproprion
imipenem/cilastatin |
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Drug rxn:
Tardive dyskinesia |
Antipsychotics
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Drug rxn:
Disulfiram-like reaction (4) |
Metronidazole
certain cephalosporins procarbazine sulfonylureas |
M
C P S |
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Drug rxn:
Nephrotoxicity/neurotoxicity |
Polymyxins
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Drug Reaction:
Nephrotoxicity/ototoxicity (3) |
Aminoglycosides
loop diuretics cisplatin |
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P-450 interactions
INDUCERS (Queen Barb takes Phen-phen and Refuses Greasy Carbs) |
Quinidine
Barbituates Phenytoin Rifampin griseofulvin Carbamazepine St. John's wort |
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P-450 interactions
INHIBITORS (Inhibitors Stop Cyber-Kids from Eating Grapefruit) |
Isoniazid
Sulfonamides Cimetidine Ketoconazole Erythromycin Grapefruit juice |
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P-450 interactions
INDUCERS (Queen Barb takes Phen-phen and Refuses Greasy Carbs) |
Quinidine
Barbituates Phenytoin Rifampin griseofulvin Carbamazepine St. John's wort |
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P-450 interactions
INHIBITORS (Inhibitors Stop Cyber-Kids from Eating Grapefruit) |
Isoniazid
Sulfonamides Cimetidine Ketoconazole Erythromycin Grapefruit juice |
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28 y/o chemist presents with MPTP exposure.
What neurotransmitter is depleted? |
Dopamine
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Woman taking tetracyclinne exhibits photosensitivity.
What are the clinical manifestations? |
Rash on sun-exposed regions of the body.
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African-American man who goes to africa develops a hemolytic anemia after taking Malarial prophylaxis.
What is the enzyme deficiency? |
Glucose-6-phosphate dehydrogenase
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27 year old female with a history of psychiatric illness now has urinary retention due to a neuroleptic
What is it treated with |
Bethanechol
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Patient with recent kidney transplant is on cyclosporine for immunosuppression. Requires antifungal agent for candidiasis.
What antifungal drug would result in cyclosporine toxicity? |
Ketoconazole
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Patient is on carbamazepine
What routine workup should always be done? |
LFTs
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23 y/o female who is on rifampin for TB prophylaxis and on birth control gets pregnany. Why?
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Rifampin augments estrogen metabolism in the liver, rendering it less effective.
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Formula for volume of distribution
Vd = ? High Vd means what? Low Vd means what |
Amount of drug in the body / plasma drug concentration
High Vd means distributes in tissues Low Vd means distributes in plasma |
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What is clearence?
CL = ? |
Rate of elimination of drug / plasma drug concentration
or Vd x Ke (elimination constant) |
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Half life
How long does it take for a drug infused at a constant rate to reach 94% of steady state |
Half life = the amount of time required to change the amount of drug in the body by 1/2 during elimination
A drug infused at a constant rate reaches 94% of steady state after 4 half lives. |
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what is the formula for half life?
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T1/2 = (0.7 x Vd) / CL
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