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72 Cards in this Set

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Antidotes:
Acetaminophen
N-acetylcysteine
Antidotes:
Salicylates
Alkanize urine, dialysis
Antidotes:
Anticholinesterases
Organophosphates
Atropine, pralidoxime
Antidotes:
Antimuscarinic
Anticholinergic agents
Physostigmine salicylate
Antidotes:
B-blockers
Glucagon
Antidotes:
Digitalis

(5 things)
Stop dig
normalize K+
lidocaine
Anti-dig Fab fragments
Mg++
Antidotes:
Iron
Deferoxamine
Antidotes:
Lead
(4)
CaEDTA
dimercaprol
succimer
penicillamine
Antidotes:
Arsenic
Mercury
Gold
Dimercaprol (BAL)
Succimer
Antidotes:
Copper
arsenic
gold
Penicillamine
Antidotes:
Cyanide
(3)
Nitrite
Hydroxocolbamin
Thiosulfate
Antidotes:
Methemoglobin
Methylene blue
Antidotes:
Carbon Monoxide
100% O2
hyperbaric O2
Antidotes:
Methanol
ethylene glycol
Ethanol, dialysis, fomepizole
fomepizole is a competitive inhibitor of alcohol dehydrogenase
Antidotes:
Opioids
Naloxone/naltrexone
Antidotes:
Benzodiazepines
Flumazenil
Antidotes:
TCAs
NaHCO3
Antidotes:
Heparin
Protamine
Antidotes:
Warfarin
(2)
Vitamin K
FFP
Antidotes:
tPA
Streptokinase
Aminocaprotic acid
Lead poisioning in a kid
Succimer
"sucks" to be a kid who eats lead
Lead poisoning in an adult
EDTA and Dimercaprol
Signs of lead poisoning
Lead Lines on gingivae and epiphysis of long bones
Encephalopathy and Erythrocyte basophilic stippling
Abdominal colic and sideroblastic Anemia
Drops - wrist and foot drop
Drug rxn:
Atropine like side effects
Tricyclics
Drug rxn:
Cardiac toxicity (2)
Doxorubicin (adriamycin)
daunorubicin
Drug rxn:
Coronary vasospasm
Cocaine
Drug rxn:
Cutaneous flushing (4)
Niacin,
Ca++ Channel blockers
adenosine
vancomycin
Drug rxn:
Torsades des pointes
Class III (sotalol)
Class IA (quinidine) antiarrhythmics
cisapride
Drug rxn:
Agranulocytosis (3)
Clozapine
carbamazepine
colchicine
two antiepileptics
One anti-gout
Drug rxn:
Aplastic anemia (3)
Chloramphenicol
benzene
NSAIDs
Drug rxn:
Gray Baby syndrome
Chloramphenicol
Drug rxn:
Hemolysis in G6PD deficient pts
(I Never Prescribe Aspirin If Ibuprofen Suffices)
Isoniazid (INH)
Nitrofurantoin
Primaquine
Aspirin
Ibuprofen
Sulfonamides
Drug rxn:
Thrombotic Complications
OCPs
(e.g., estrogens and progestins)
Drug rxn:
Cough
ACE inhibitors
note: no cough in losartan and AARB
Pulmonary fibrosis

(3)
Bleomycin
AMIODARONE
busulfan
Drug rxn:
Acute cholestatic hepatitis
Macrolides
Drug rxn:
Focal to massive hepatic necrosis
3 drugs
1 mushroom
Halothane
Valproic acid
acetaminophen
Amanita phalloides (death cap)
Drug rxn:
Hepatitis
INH
Drug rxn:
Pseudomembranous colitis
(2)
Clindamycin
Ampicillin
Drug rxn:
Adrenocortical insufficiency
Glucocorticoid withdrawl (HPA suppression)
Drug rxn:
Gynecomastia
(some drugs create awesome knockers) +e
Spironolactone
Digitalis
Cimetidine
chronic Alcohol abuse
estrogens
Ketoconazole
Drug rxn:
Hot flashes
Tamoxifen
Drug rxn:
Gingival hyperplasia
Phenytoin
Drug rxn:
Osteoporosis
(2)
Corticosteroids
Heparin
Drug rxn:
Photosensitivity
(SAT for a photo)
Sulfonamides
Amiodarone
Tetracycline
Drug rxn:
SLE - like syndrome
(it's not HIPP to have lupus)
Hydralazine
INH
Procainamide
Phenytoin
Drug rxn:
Tendonitis, tendon rupture, cartilage damage (kids)
Fluoroquinolones
Drug rxn:
Fanconi's syndrome
Expired tetracycline
proximal tubule of the kidney doesn't work
Drug rxn:
Interstitial nephritis
Methicillin
Drug rxn:
Hemorrhagic Cystitis
(2)
Cyclophosphamide
Ifosfamide
Drug rxn:
Cinchonism

What is cinchonism? See hint
Quinidine
quinine
tinnitus, headache, deafness, occasionally anaphylactic shock
Drug rxn:
Diabetes insipidus
Lithium
demeclocycline
Drug rxn:
Seizures
buproprion
imipenem/cilastatin
Drug rxn:
Tardive dyskinesia
Antipsychotics
Drug rxn:
Disulfiram-like reaction
(4)
Metronidazole
certain cephalosporins
procarbazine
sulfonylureas
M
C
P
S
Drug rxn:
Nephrotoxicity/neurotoxicity
Polymyxins
Drug Reaction:
Nephrotoxicity/ototoxicity
(3)
Aminoglycosides
loop diuretics
cisplatin
P-450 interactions
INDUCERS
(Queen Barb takes Phen-phen and Refuses Greasy Carbs)
Quinidine
Barbituates
Phenytoin
Rifampin
griseofulvin
Carbamazepine
St. John's wort
P-450 interactions
INHIBITORS
(Inhibitors Stop Cyber-Kids from Eating Grapefruit)
Isoniazid
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice
P-450 interactions
INDUCERS
(Queen Barb takes Phen-phen and Refuses Greasy Carbs)
Quinidine
Barbituates
Phenytoin
Rifampin
griseofulvin
Carbamazepine
St. John's wort
P-450 interactions
INHIBITORS
(Inhibitors Stop Cyber-Kids from Eating Grapefruit)
Isoniazid
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice
28 y/o chemist presents with MPTP exposure.

What neurotransmitter is depleted?
Dopamine
Woman taking tetracyclinne exhibits photosensitivity.

What are the clinical manifestations?
Rash on sun-exposed regions of the body.
African-American man who goes to africa develops a hemolytic anemia after taking Malarial prophylaxis.

What is the enzyme deficiency?
Glucose-6-phosphate dehydrogenase
27 year old female with a history of psychiatric illness now has urinary retention due to a neuroleptic

What is it treated with
Bethanechol
Patient with recent kidney transplant is on cyclosporine for immunosuppression. Requires antifungal agent for candidiasis.

What antifungal drug would result in cyclosporine toxicity?
Ketoconazole
Patient is on carbamazepine

What routine workup should always be done?
LFTs
23 y/o female who is on rifampin for TB prophylaxis and on birth control gets pregnany. Why?
Rifampin augments estrogen metabolism in the liver, rendering it less effective.
Formula for volume of distribution

Vd = ?
High Vd means what?
Low Vd means what
Amount of drug in the body / plasma drug concentration

High Vd means distributes in tissues
Low Vd means distributes in plasma
What is clearence?

CL = ?
Rate of elimination of drug / plasma drug concentration

or

Vd x Ke (elimination constant)
Half life

How long does it take for a drug infused at a constant rate to reach 94% of steady state
Half life = the amount of time required to change the amount of drug in the body by 1/2 during elimination

A drug infused at a constant rate reaches 94% of steady state after 4 half lives.
what is the formula for half life?
T1/2 = (0.7 x Vd) / CL