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11 Cards in this Set
- Front
- Back
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Diphenhydramine
Dimenhydrinate Chlorpheniramine |
MOA: Reversible H1 receptor inhibitor (FIRST generation)
Uses: Allergy, motion sickness, sleep aid Toxicity: Sedation, Antimuscarinic, anti-alpha-adrenergic |
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Loratadine
Fexofenadine Desloratadine Ceterizine |
MOA: Reversible inhibitor of H1 receptor (SECOND generation)
Uses: allergy Toxicity: less sedating than 1st gen b/c decreased CNS entry |
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Isoproterenol
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nonspecific beta-agonist; relaxes bronchial sm. muscle through beta-2
adverse rxn: tachycardia (beta-1) |
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Albuterol
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beta-2 agonist
use: acute exacerbation |
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Salmeterol
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beta-2 agonist
use: prophylaxis (long-acting) toxicity: tremor, arrhythmia |
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Theophylline (methylxanthines)
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phosphodiesterase inhibitor, decreasing cAMP hydrolysis --> bronchodilation
narrow therapeutic index (cardio and neurotoxic) P-450 metabolism |
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Ipratropium
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block muscarinic receptors (prevent bronchoconstriction)
use for COPD, asthma |
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Cromolyn
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prevents mast cell release of mediators
use: asthma PPX toxicities rare |
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Beclomethasone
Prednisone |
inhibits synthesis of cytokines, inactivates NF-kappaB (tx factor for TNF-alpha)
use: 1st line for chronic asthma |
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Zileuton
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5-lipoxygenase pathway inhibitor (blocks: arachidonic acid --> leukotriene)
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Zafirlukast
Montelukast |
block leukotriene receptors
use: good for ASA-induced asthma |
