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16 Cards in this Set
- Front
- Back
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Finasteride
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MOA: 5alpha-reductase inhibitor
use: BPH, male-pattern baldness |
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Flutamide
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MOA: inhibits androgens at testosterone receptor
use: prostate carcinoma |
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Ketoconazole
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MOA: inhibits steroid synthesis (desmolase inhibitor)
use: PCOS (hirsutism) tox: gynecomastia, amenorrhea, decr. libido |
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Spironolactone
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MOA: antiandrogen (inhibits steroid binding)
use: hirsutism in PCOS tox: gynecomastia, amenorrhea, decreases libido |
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Leuprolide
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MOA: GnRH
use: infertility (pulsatile), prostate cancer (cont), ibroids tox: antiandrogen, n/v |
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Sildenafil
Vardenafil |
MOA: cGMP phosphodiesterase inhibitor
use: ED tox: HA, flushing, dyspepsia, impaired blue-green color vision, hypotension |
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Mifepristone (RU-586)
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MOA: progestin receptor inhibitor
use: abortion; give with PGE1 (misoprostol) tox: bleeding, n/v/a, abd. pain |
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Dinoprostone
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MOA: PGE2 analog
use: labor induction |
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Ritodrine
Terbutaline |
MOA: beta-2 agonist
use: reduce premature uterine contractions |
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Anastrozole
Examestane |
MOA: aromatase inhibitor
use: postmenopausal with breast CA |
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Testosterone
(methyltestosterone) |
use: hypogonadism; promote 2ary sex characteristics; stimulates anabolism to promote recovery p/burn or injury; treat ER+ breast CA
tox: masculinization, gonadal atrophy, premature epiphyseal plate closure, incr LDL/decr HDL |
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Estrogens
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use: hypogonadism/ovarian failure, menstrual, HRT, men with androgen-dependent prostate CA
tox: incr risk endom CA, bleeding, clear cell adenocarcinoma (DES in utero), thrombi contraind: ER+ breast CA |
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Progestins
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MOA: reduces growth and increases vascularization of endometrium
use: OCPs, tx or endom CA, abnl uterine bleeding |
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Clomiphene
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MOA: SERM, partial agonist estrogen receptor at hypothalamus (inhibits neg feedback)
use: infertility, PCOS tox: hot flashes, enlarged ovaries, multiple gestation, visual disturbances |
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Tamoxifen
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MOA: SERM, breast tissue antagonist
use: ER+ breast cancer |
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Raloxifene
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MOA: SERM, bone agonist; anti-estrogen on uterus/breast
use: osteoporosis |
