Pharm Quiz Anti-Seizure

Front 1

The initial site of this discharge is referred to as the _____

Back 1

focus

Front 2

Generalized Seizure Types

-

-

-

Back 2

Tonic-Clonic

Absence Seizures

Status Epilepticus

Front 3

________ consists of alternating periods of synchronous muscle jerks (clonic) and muscle rigidity (tonic phase) with impairment of consciousness; followed by a period of CNS depression.

Back 3

Tonic-Clonic/Grand mal

Front 4

_______is a brief, frequent losses of consciousness with staring and fluttering eyelids that last 10-30 seconds.

Back 4

Absence Seizures (Petit mal)

Front 5

_____________ is a persistent general seizure (>30 minutes) which can be life threatening if not stopped.

Back 5

Status Epilepticus

Front 6

____________acts to inhibit the sodium channels in the post-synaptic neuron, but only when repeat frequent firing of the neuron has occurred so that the neuron has not had time to completely repolarize

Back 6

Phenytóin (Dilántin)

It inhibits Neuron Firing

Front 7

Phenytóin has a _______ therapeutic range and

substantial variation in ________ and _______.

Back 7

narrow

absorption and metabolism

Front 8

With Phenytoin _________ varies from person to person.

Back 8

Bioavailability

Front 9

Phenytoin induce _______

Back 9

Cyt-p-450

Front 10

Side effects of Phenytoin

-

-

-

-

Back 10

Sedation

Gingival hyperplasia

dermatitis/steven-johnson syndrome

teratogenicity

Front 11

_________is a new drug related to phenytóin

Back 11

Fosphenytoin (Cerebyx)

Front 12

Topiramate(Topomax) appears to inhibit _______ and augment the action of ______.

It has official FDA approval for _____ ________ _________

Back 12

NA+ Channels

GABA receptors

Prevention of Migraines

Front 13

___________ is used primarily to treat Grand Mal Seizures and also appears to inhibit ______ _______

Back 13

Carbamázepine (Tégretol)

NA Channels

Front 14

______________works as an anti-seizure medication by increasing sensitivity of ________ receptors. Sedation may be a problem. It is effective against all forms except _______ seizures.

Back 14

Phenobaritol, GABA, Absence

Front 15

This anti-convulsant works for all types of seizures

Back 15

Depakene/Depakote

Front 16

Depakote has __________ which makes it disolve only in the gut instead of the stomach

Back 16

Enteric coating

Front 17

Depakote and Depakene work by inhibiting _______ and _______

Back 17

sodium channel depolarization and T-type Ca channel depolarization

Front 18

Lamictal and Keppra have _____ ______ _______ than depakote

Back 18

Fewer side effects

Front 19

These 2 drugs are used for tonic-clonic seizures and are said to have fewer side effects.

Back 19

Lamictal/Keppra

Front 20

These 2 drugs stop status epilepticus

Back 20

Lorazepam/Diazepam

Front 21

This med is used in treatment of absence seizures

Back 21

Clonazepam (Klonopin)

Front 22

80% of this drugs prescriptions are being perscribed for offlabel uses such as mood swings in bipolar disorder, neuralgic pain (diabetic neuralgic pain, shingles), nystagmus, Parkinson’s disease, and schizophrenia.

Back 22

Gabapentin (Neurontin)

Front 23

Gabapentin (Neurontin) acts to inhibit ____ channels in the brain

Back 23

Ca+

Front 24

___________ is a newer version of gabapentin that is FDA approved for _________ as well as _____________ and has now been approved for the treatment of __________.

Back 24

Pregabalin (Lyrica), partial seizures, neurological pain, fibromyalgia

Front 25

The important alternative seizure treatment to know is _____________

Back 25

Ketogenic Diet (high fat, low carb, like atkins)