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25 Cards in this Set
- Front
- Back
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Immunosuppressants (8)
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Cyclophosphamide
Azathioprine Mycophenolate mofetil Methotrexate Cyclosporine Tacrolimus Rapamycin Glatiramer |
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Mechanism:
Cyclophosphamide |
Prodrug-
Produces alkylating agents Inhibits proliferative responses |
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Mechanism:
Azathioprine |
Becomes 6-mercaptopurine
Inhibits proliferative response |
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Mechanism:
Mycophenolate mofetil |
Inhibits T and B Lymphocyte proliferation through inhibition of purine synthesis
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Mechanism:
Methotrexate |
Inactivates dihydrofolate
reductase Stimulates release of adenosine Inhibits neutrophil fxn ANTIINFLAMMATORY |
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Mechanism:
Cyclosporine |
Inhibits cyclophilin binding
protein (inhibits T-cell activation and cytokine release) |
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Mechanism:
Tacrolimus and Rapamycin |
Inhibits FK binding protein
(Inhibits T-cell activation and cytokine release) |
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Mechanism:
Glatiramer |
Downregulates specific immune response in MS (antigen specific)
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Uses:
Cyclophosphamine |
Lupus nephritis
Systemic Vasculitudes Severe Autoimmune Disease |
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Uses:
Azathioprine |
Kidney Transplant prophylaxis
Lupus RhA (not first line) |
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Uses:
Mycophenolate mofetil |
Kidney Transplant Prophylaxis
Wide use Lupus |
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Uses:
Methotrexate |
RHa
Psoriasis To reduce dosage of glucocorticoids in chronic vasculitis |
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Uses:
Cyclosporine |
Organ Transplant Prophylaxis
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Uses:
Rapamycin |
Organ Transplant Prophylaxis
Allows lower doses of cyclosporine or tacrolimus (decrease toxicity) |
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Uses:
Tacrolimus |
Liver Transplant prophylaxis (when cyclosporine fails)
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Uses:
Glatiramer |
Treat Multiple Sclerosis
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Side Effects:
Cyclophosphamine |
Myelosuppression
Hemorrhagic Cystitis Can cause tumors |
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Side Effects:
Azathioprine |
Bone Marrow Suppression
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Side Effects:
Mycophenolate mofetil |
Neutropenia
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Side Effects:
Methotrexate |
Liver Fxn Abnormalities
Bone Marrow Suppression Nausea |
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Uses:
Cyclosporine |
Nephrotoxicity
Neurotoxicity Hepatoxicity Hypertension |
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Uses:
Tacrolimus |
Nephrotoxicity
Hepatoxicity Neurotoxicity |
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Uses:
Rapamycin |
None
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Purpose of immune system
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protects host from invading organisms and growing neoplastic cells
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autoimmune diseases do what?
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react against self proteins
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