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9 Cards in this Set
- Front
- Back
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Kidney Additional Functions
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Maintains BP
Erythropoietin Regulates 1,25 Vitamin D3 Renin production Gluconeogenesis |
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Regulators of GFR
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Vasoconstriction of afferent arteriole decreases GFR
- Sympathetics - Catecholamines - Endothelin Vasoconstriction of efferent arteriole increases GFR - Renin / Angiotensin II Vasodilation increases GFR - Prostaglandin E2, I2 - NO |
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Aldosterone, ANP, PTH & Vitamin D3
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Aldosterone - Increases sodium and thus water, decreases K
ANP - Decreases Na & thus water PTH - Increase Ca2+ but decreases PO4 Vit D3 - Indirectly counters PTH |
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GFR rate & Filtration cutoff.
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120ml/min 180L/d about 20% of plasma.
70kD is cutoff but high negative charge also traps most proteins. |
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Kf & Influences
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Filtration coefficient 12.5ml/min/mmHg
HTN & Diabetes decreases capillary surface area & Increase glomerular capillary membrane thickness. Reducing Kf |
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Functional anatomy, Transport mechanisms & Regulation
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PCT - 50%, Na H+ exchanger
Descending limb - 20% TAL - 20% NKCC in DCT - 5% Na Cl cotransporter in Collecting duct - 5% Just sodium -Aldosterone & ATII increases expression of Na/K ATPase - Aldosterone increases Na+ in DCT - ATII increases Na/H exchanger in PCT |
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Drug classes on kidney function
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Na/K - Ace inhibitors & Aldosterone antagonists
Na/H - Ace inhibitors & Carbonic anhydrase inhibitors 50% NKCC - Loop diuretics 20% Na-Cl - Thazides 5% Na+ - Aldosterone antagonists 5% * Aldosterone antagonists are K+ Sparing. |
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Functional anatomy, Transport mechanisms & Regulation
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PCT - 50%, Na H+ exchanger
Descending limb - 20% TAL - 20% NKCC in DCT - 5% Na Cl cotransporter in Collecting duct - 5% Just sodium -Aldosterone & ATII increases expression of Na/K ATPase - Aldosterone increases Na+ in DCT - ATII increases Na/H exchanger in PCT |
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Drug classes on kidney function
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Na/K - Ace inhibitors & Aldosterone antagonists
Na/H - Ace inhibitors & Carbonic anhydrase inhibitors 50% NKCC - Loop diuretics 20% Na-Cl - Thazides 5% Na+ - Aldosterone antagonists 5% * Aldosterone antagonists are K+ Sparing. |
