Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
resting tone of bronchial smooth m. is set by
blockade of what receptors can reverse ____-induced broncho spasm |
-ACh
-M3, vagal-induced |
|
|
Muscarinic Antagonists:
mech (generally) do not decrease problems w/ this tx (2) |
-block ACh -> decreased m. tone
-mucociliary transport -musc receptors are only involved in part of the response, : . limited effect -amount of musc receptors varies greatly from pt to pt : . highly variable response |
|
|
which musc antag. inhibits augmented mucous secretion?
|
-atropine
|
|
|
Atropine sulfate:
class admin SEs (4) |
-musc. antag (asthma use, infrequent))
-aerosol -xerostomia, urinary retention, tachycardia, loss of visual accommodation |
|
|
Ipratropium bromide:
class admin pros (2) |
-musc antag for asthma, frequently used
(quaternary ammonium analog of atropine) -aerosol -localized effect -proven to decrease hospitalization rates in severly asthmatic children |
|
|
when an agonist is used as tx, the receptors are normally _______ regulated due to ________.
What drug class is different |
-down
-negative feedback(?) -corticosteroids. They up-regulate |
|
|
mech of CSs: (short term)
inhibit (3) reduce ___-regulate _________ |
-chemotaxins, spasmogens, vasodilators
-eosinophil recruitment -up-regulate B2 receptors |
|
|
Mech of CSs:
long term |
-reduce synth of IL-3 --> down mast cell production --> down asthmatic early phase response
|
|
|
Drugs given by inhalation (4)
|
-Beclomethasone
-Triamcinolone -Dexamethasone -Flunisolide |
|
|
Beclomethasone:
class admin SE how to avoid |
-CS
-inhalation -oropharyngeal candidiasis (thrush) -have pt rinse and spit after tx |
|
|
Triamcinolone:
class admin SE how to avoid |
-CS
-inhilation -oropharyngeal candidiasis (thrush) -have pt rinse and spit after tx |
|
|
Dexamethasone:
class admin SE how to avoid |
-CS
-inhilation -oropharyngeal candidiasis (thrush) -have pt rinse and spit after tx |
|
|
Flunisolide
class admin SE how to avoid |
-CS
-inhilation -oropharyngeal candidiasis (thrush) -have pt rinse and spit after tx |
|
|
oral prednisone, prednisolone is used for what
|
-severe or rapidly worsening asthma
|
|
|
Zileuton:
class mech potency duration need to monitor |
-anti-Leukotriene, 5-lipoxygenase inhib
-low & -short (: . not that useful) -hepatic fct |
|
|
slide 39
|
do slide 39
|
