Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
therapeutic uses of epi/norepi (3)
|
1) shock: restores bp, correct vascular distrib
2) cardiac stimulant after heart block 3)local vasoconstrictor in dentistry |
|
|
epi acts on which receptors during Tx for shock
|
-alpha: constricts peripheral vessels (increase diastolic bp)
-beta1: ups heart rate (systolic bp) -beta2: ups blood flow to vital organs |
|
|
effects of adrenergic agonist as cardiac stimulant
|
Beta1: to up heart rate
-best is dobutamine -> selective beta1 agonist : . no changes in bp |
|
|
why do we use epi in LA instead of a selective alpha1? (2)
|
-safer when drug has both alpha and beta activity
-use of alpha selective can result in tissue necrosis |
|
|
Nasal decongestant (2)
|
-alpha agonist: reduces glandular flow
-pnenylephrine, neosinephrine |
|
|
adrenergic agonist in the eye (2)
|
-alpha agonist will cause pupil to dilate w/out cycloplegia (b/c no alphas in ciliary m.)
-Tx for hypersecretion glaucoma |
|
|
Asthma (2)
|
-beta2, for bronchodilation
-terbutaline, albutarol |
|
|
anti-htn drugs (3)
|
-alpha 2 agonists
-reduces norepi release -reduces sympathetic tone -> reduces bp |
|
|
ephedrine (3)
|
-releases catecholamines in brain
-vasoconstrictor -dangerous because of CNS effects |
|
|
epinephrine reversal (3)
|
-high dose epi -> pressor response -BUT, if ergot (eat fungus -> crazy ppl) is injected first -> DEpressor response
-is unmasking of alpha1 response -> leaving only beta2 response |
|
|
alpha blockers (6)
|
-epi reversal
-reflexive tachycardia -vasodilation -nasal congestion -ups GI tract -miosis |
|
|
Phentolamine:
class uses (3) |
-alpha blocker prototype
Used for: 1) pheochromocytoma diagnosis: tumor in adrenal medulla -> high blood epi. Can urine test 2) prevent htn during adrenal medulla surgery 3) controls htn during general anesthesia |
|
|
Phenoxybenzamine
|
-long acting alpha blocker
-forms covalent bond w/ receptor -used to lower bp, or produce orthostatic hypotn during surgery |
|
|
Prazosin, Minipress
|
-selective alpha1 blocker
-will lower bp w/out tachycardia |
|
|
in case of prostate hypertrophy, helps pt urinate (3)
|
-Tarazosin, Flomax
-selective alpha1 blocker -relaxes bladder sphincter |
|
|
Propranolol:
class uses side effect |
-beta blocker (-lol is always BB)
-antihtn, cardiac arrhythmias, angina, post MI, migraines, hypersecretory glaucoma -bronchiolar constriction |
|
|
beta blockers:
dental caution |
-epi is like pure alpha agonist -> pressor response -> increased risk of tissue necrosis, etc
|
