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36 Cards in this Set
- Front
- Back
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Omalizumab
Use |
asthma and allergic rhinitis
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Omalizumab
Mech |
anti IgE antibody
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Histamine Release Inhibitors (Cromones)
Cromolyn asthma use |
long term
inhibit cold and exercise asthma can use prior to exercise/antigen exposure |
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Histamine Release Inhibitors (Cromones)
cromolyn Mech |
prevent antigen indecde release of mediators from mast cells
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Histamine Release Inhibitors (Cromones)
Cromolyn Phamako |
inhale
poorly absorbed |
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Histamine Release Inhibitors (Cromones)
Cromolyn Rhinitis use |
nasal spray or eye solution
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Histamine Release Inhibitors (Cromones)
Nedocromil Mech |
inhib activation and attraction of macrophages in lung and circulating immune cells
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Histamine Release Inhibitors (Cromones)
Nedocromil Use |
long term
prior to exercise or exposure to allergen |
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Histamine Release Inhibitors (Cromones)
Nedocromil Pharmako |
inhale
poorly absorbed |
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Histamine Release Inhibitors (Cromones)
Nedocromil Rhinitis use |
nasal spray or eye solution
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Leukotriene Modifiers
5-lipooxygenase inhib Zileuton Features |
stops bronchospasm and inflame response
long term |
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Leukotriene Modifiers
5-lipooxygenase inhib Zileuton Pharmaco |
orally
short duration, metab by liver |
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Leukotriene Modifiers
5-lipooxygenase inhib Zileuton Contraindications |
liver disease
if patient on other drugs that are metab by liver interefers with warfin, theophylinn, propanolol |
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Leukotriene Modifiers
leukotriene receptor antagonists Montelukast Features |
stops bronchospasm and inflame response
long term |
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Leukotriene Modifiers
leukotriene receptor antagonists Montelukast Pharmaco |
orally
long duration metab by liver excreted into bile |
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Cholinergic Receptor Antagonists
Ipratropium - asthma Effects |
bronchodilation
reduces secretion |
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Cholinergic Receptor Antagonists
Ipratropium - asthma Features |
slow onset long duration
limited side effects b.c minimal amt absorbed long term control |
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Muscarinic Cholinergic Receptor Antagonists
Ipratropium - rhinitis Mech |
reduces secretions by cold air, spicy food, and allergic rhinitis
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β Adrenergic Receptor Agonists
Epinephrine Features |
inhale in emergent situations
immediate onset, short duration nonselective |
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β Adrenergic Receptor Agonists
Isoproterenol Features |
inhale or PO
immediate and short selective to Beta |
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β Adrenergic Receptor Agonists
Metaproterenol Features |
rapid and intermediate duration
inhale B2 selective |
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β Adrenergic Receptor Agonists
Pirbuterol Features |
rapid onset, intermediate duration
inhale B2 selective |
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β Adrenergic Receptor Agonists
Albuterol Features |
intermediate onset, long duration
inhale or oral B2 |
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β Adrenergic Receptor Agonists
Lev-albuterol Features |
enantomer
more biologically active inhale, B2 less CV side E |
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β Adrenergic Receptor Agonists
Side E |
vasoconstriction, cardiac stim
refractoriness - receptor down regulation can mask inflame |
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Methylxanthines
Theophylline Mech |
block adenosine receptors
at high doses 1. inhibi cAMP phosphodiesterase 2. alter translocation of intracellular Ca |
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Methylxanthines
Theophylline Effects |
1. relax airway SM
2. inc mucociliary clearance 3. inhib antigen induced relase of mediators 4. stim resp center 5. ionotripic and chonotropic effects of heart 6. vasodilation of BV except cerebral |
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Methylxanthines
Theophylline Use |
acute asthma is B-agonist not good enough
long term apnea/COPD |
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Methylxanthines
Theophylline Side E MANY! |
headache, nervousness, learning or behavioral issues
neausea, termor, cardiac arrhythmias |
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Methylxanthines
Theophylline Side E - Reasons |
Narrow TI, titrate up to dose after weeks
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Methylxanthines
Theophylline Pharmaco |
Good oral bioavailabilty
widely distrubuted (BBB and placenta) hepatic metab wide variation of half life |
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Methylxanthines
Theophylline Half Life Increased by: |
hepatic disease
COPD Cimetidine marcolide antibiotics acute alcohol |
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Methylxanthines
Theophylline Half Life dec by: |
smoking
chronic alcohol chronoic phenobarbital phetonin |
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Corticosteroid
Drugs Prototype |
Beclomethasone
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Corticosteroid
Drugs Nebulizer |
Budesonide
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Corticosteroid
Drugs Emergent |
Methylprednisone
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