Pharm Psych

Front 1

Methylphenidate mechanism of action?

Back 1

Increase presynaptic norepinephrine release.

Front 2

Methylphenidate uses?

Back 2

ADHD.

Front 3

Haloperidol mechanism of action?

Back 3

High potency typical antipsychotic. D2 antagonist; inhibits G(i) thus increases cAMP.

Front 4

Haloperidol uses?

Back 4

Schizophrenia, Tourette's syndrome, acute mania, psychosis. Huntington's disease.

Front 5

Haloperidol side effects?

Back 5

Neuromalignant syndrome, tardive dyskinesia (extrapyramidal side effect), hyperprolactinemia leading to galactorrhea. Antimuscarinic effects (dry mouth, constipation) and anti-alpha adrenergic effects (hypotension) and anti histamine effects (sedation).

Front 6

Trifluoperazine mechanism of action?

Back 6

High potency typical antipsychotic. D2 antagonist; inhibits G(i) thus increases cAMP.

Front 7

Trifluoperazine uses?

Back 7

Schizophrenia, Tourette's syndrome, acute mania, psychosis.

Front 8

Trifluoperazine side effects?

Back 8

Neuromalignant syndrome, tardive dyskinesia (extrapyramidal side effect), hyperprolactinemia leading to galactorrhea. Antimuscarinic effects (dry mouth, constipation) and anti-alpha adrenergic effects (hypotension) and anti histamine effects (sedation).

Front 9

Fluphenazine mechanism of action?

Back 9

High potency typical antipsychotic. D2 antagonist; inhibits G(i) thus increases cAMP.

Front 10

Fluphenazine uses?

Back 10

Schizophrenia, Tourette's syndrome, acute mania, psychosis.

Front 11

Fluphenazine side effects?

Back 11

Neuromalignant syndrome, tardive dyskinesia (extrapyramidal side effect), hyperprolactinemia leading to galactorrhea. Antimuscarinic effects (dry mouth, constipation) and anti-alpha adrenergic effects (hypotension) and anti histamine effects (sedation).

Front 12

Thioridazine mechanism of action?

Back 12

Low potency typical antipsychotic. D2 antagonist; inhibits G(i) thus increases cAMP.

Front 13

Thioridazine uses?

Back 13

Schizophrenia, Tourette's syndrome, acute mania, psychosis.

Front 14

Thioridazine side effects?

Back 14

RETINITIS PIGMENTOSA. Neuromalignant syndrome, tardive dyskinesia (extrapyramidal side effect), hyperprolactinemia leading to galactorrhea. Antimuscarinic effects (dry mouth, constipation) and anti-alpha adrenergic effects (hypotension) and anti histamine effects (sedation).

Front 15

Chlorpromazine mechanism of action?

Back 15

Low potency typical antipsychotic. D2 antagonist; inhibits G(i) thus increases cAMP.

Front 16

Chlorpromazine uses?

Back 16

Schizophrenia, Tourette's syndrome, acute mania, psychosis.

Front 17

Chlorpromazine side effects?

Back 17

Neuromalignant syndrome, tardive dyskinesia (extrapyramidal side effect), hyperprolactinemia leading to galactorrhea. Antimuscarinic effects (dry mouth, constipation) and anti-alpha adrenergic effects (hypotension) and anti histamine effects (sedation).

Front 18

Olanzapine mechanism of action?

Back 18

Atypical antipsychotic. 5-HT2, alpha, H1, and D2 antagonist. Inhibits G(i) and increases cAMP.

Front 19

Olanzapine uses?

Back 19

Schizophrenia (both positive and negative symptoms), OCD, anxiety disorder, depression, mania, and Tourette's syndrome.

Front 20

Olanzapine side effects?

Back 20

Less EPS and anticholinergic side effects vs typical antipsychotics. Significant weight gain.

Front 21

Clozapine mechanism of action?

Back 21

Atypical antipsychotic. 5-HT2, alpha, H1, and D2 antagonist. Inhibits G(i) and increases cAMP.

Front 22

Clozapine uses?

Back 22

Schizoprhenia.

Front 23

Clozapine side effects?

Back 23

Agranulocytosis (must do weekly WBC monitoring). Less EPS and anticholinergic side effects vs typical antipsychotics. Significant weight gain.

Front 24

Quetiapine mechanism of action?

Back 24

Atypical antipsychotic. 5-HT2, alpha, H1, and D2 antagonist. Inhibits G(i) and increases cAMP.

Front 25

Quetiapine uses?

Back 25

Schizoprhenia.

Front 26

Quetiapine side effects?

Back 26

Less EPS and anticholinergic side effects vs typical antipsychotics.

Front 27

Risperidone mechanism of action?

Back 27

Atypical antipsychotic. 5-HT2, alpha, H1, and D2 antagonist. Inhibits G(i) and increases cAMP.

Front 28

Risperidone uses?

Back 28

Schizoprhenia.

Front 29

Risperidone side effects?

Back 29

Less EPS and anticholinergic side effects vs typical antipsychotics.

Front 30

Aripiprazole mechanism of action?

Back 30

Atypical antipsychotic. 5-HT2, alpha, H1, and D2 antagonist. Inhibits G(i) and increases cAMP.

Front 31

Aripiprazole uses?

Back 31

Schizoprhenia.

Front 32

Aripiprazole side effects?

Back 32

Less EPS and anticholinergic side effects vs typical antipsychotics.

Front 33

Ziprasidone mechanism of action?

Back 33

Atypical antipsychotic. 5-HT2, alpha, H1, and D2 antagonist. Inhibits G(i) and increases cAMP.

Front 34

Ziprasidone uses?

Back 34

Schizoprhenia.

Front 35

Ziprasidone side effects?

Back 35

Less EPS and anticholinergic side effects vs typical antipsychotics.

Front 36

Lithium mechanism of action?

Back 36

Inhibits phosphoinositol cascade.

Front 37

Lithium uses?

Back 37

Mood stabilizer for bipolar disorder; blocks relapse and acute manic events. Also SIADH.

Front 38

Lithium side effects?

Back 38

Tremor, nephrogenic diabetes insipidus, hypothyroidism, teratogenic (Ebstein's abnomality of heart).

Front 39

Buspirone mechanism of action?

Back 39

Stimulates 5-HT1A receptors.

Front 40

Buspirone uses?

Back 40

Generalized anxiety disorder.

Front 41

Buspirone side effects?

Back 41

No sedation, addiction, or tolerence. Does not interact with alcohol.

Front 42

Imipramine mechanism of action?

Back 42

TCA; blocks reuptake of norepinephrine and serotonin.

Front 43

Imipramine uses?

Back 43

Major depression, bedwetting, fibromyalgia.

Front 44

Imipramine side effects?

Back 44

Convusions, coma, respiratory depression and hyperpyrexia. Due to anticholinergic effects. Prolongs QRS thus causes arrhythmias; due to inhibition of voltaged gated sodium channels in the heart. Treat with sodium bicarbonate.

Front 45

Amitriptyline mechanism of action?

Back 45

TCA; blocks reuptake of norepinephrine and serotonin.

Front 46

Amitriptyline uses?

Back 46

Major depression, fibromyalgia.

Front 47

Amitriptyline side effects?

Back 47

SIADH. Convusions, coma, respiratory depression and hyperpyrexia. Due to anticholinergic effects. Prolongs QRS thus causes arrhythmias; due to inhibition of voltaged gated sodium channels in the heart. Treat with sodium bicarbonate.

Front 48

Despiramine mechanism of action?

Back 48

TCA; blocks reuptake of norepinephrine and serotonin.

Front 49

Despiramine uses?

Back 49

Major depression, fibromyalgia.

Front 50

Despiramine side effects?

Back 50

Convusions, coma, respiratory depression and hyperpyrexia. Due to anticholinergic effects. Prolongs QRS thus causes arrhythmias; due to inhibition of voltaged gated sodium channels in the heart. Treat with sodium bicarbonate.

Front 51

Nortriptyline mechanism of action?

Back 51

TCA; blocks reuptake of norepinephrine and serotonin.

Front 52

Nortriptyline uses?

Back 52

Major depression, fibromyalgia.

Front 53

Nortriptyline side effects?

Back 53

Convusions, coma, respiratory depression and hyperpyrexia. Due to anticholinergic effects. Prolongs QRS thus causes arrhythmias; due to inhibition of voltaged gated sodium channels in the heart. Treat with sodium bicarbonate.

Front 54

Clomipramine mechanism of action?

Back 54

TCA; blocks reuptake of norepinephrine and serotonin.

Front 55

Clomipramine uses?

Back 55

Major depression, OCD, fibromyalgia.

Front 56

Clomipramine side effects?

Back 56

Convusions, coma, respiratory depression and hyperpyrexia. Due to anticholinergic effects. Prolongs QRS thus causes arrhythmias; due to inhibition of voltaged gated sodium channels in the heart. Treat with sodium bicarbonate.

Front 57

Doxepin mechanism of action?

Back 57

TCA; blocks reuptake of norepinephrine and serotonin.

Front 58

Doxepin uses?

Back 58

Major depression, fibromyalgia.

Front 59

Doxepin side effects?

Back 59

Convusions, coma, respiratory depression and hyperpyrexia. Due to anticholinergic effects. Prolongs QRS thus causes arrhythmias; due to inhibition of voltaged gated sodium channels in the heart. Treat with sodium bicarbonate.

Front 60

Amoxapine mechanism of action?

Back 60

TCA; blocks reuptake of norepinephrine and serotonin.

Front 61

Amoxapine uses?

Back 61

Major depression, fibromyalgia.

Front 62

Amoxapine side effects?

Back 62

Convusions, coma, respiratory depression and hyperpyrexia. Due to anticholinergic effects. Prolongs QRS thus causes arrhythmias; due to inhibition of voltaged gated sodium channels in the heart. Treat with sodium bicarbonate.

Front 63

Fluoxetine mechanism of action?

Back 63

Serotonin-specific reuptake inhibitors.

Front 64

Fluoxetine uses?

Back 64

Requires 2-3 weeks to take effect. Depression, OCD< bulimia, social phobias.

Front 65

Fluoxetine side effects?

Back 65

Less side effects than TCAs. GI distress, sexual dysfunction (anorgasmia). Serotonin syndrome when combined with MAOIs or other drugs that increase serotonin (tyramine). Treat with cyproheptadine.

Front 66

Paroxetine mechanism of action?

Back 66

Serotonin-specific reuptake inhibitors.

Front 67

Paroxetine uses?

Back 67

Requires 2-3 weeks to take effect. Depression, OCD< bulimia, social phobias.

Front 68

Paroxetine side effects?

Back 68

Less side effects than TCAs. GI distress, sexual dysfunction (anorgasmia). Serotonin syndrome when combined with MAOIs or other drugs that increase serotonin (tyramine). Treat with cyproheptadine.

Front 69

Sertraline mechanism of action?

Back 69

Serotonin-specific reuptake inhibitors.

Front 70

Sertraline uses?

Back 70

Requires 2-3 weeks to take effect. Depression, OCD< bulimia, social phobias.

Front 71

Sertraline side effects?

Back 71

Less side effects than TCAs. GI distress, sexual dysfunction (anorgasmia). Serotonin syndrome when combined with MAOIs or other drugs that increase serotonin (tyramine). Treat with cyproheptadine.

Front 72

Citalopram mechanism of action?

Back 72

Serotonin-specific reuptake inhibitors.

Front 73

Citalopram uses?

Back 73

Requires 2-3 weeks to take effect. Depression, OCD< bulimia, social phobias.

Front 74

Citalopram side effects?

Back 74

Less side effects than TCAs. GI distress, sexual dysfunction (anorgasmia). Serotonin syndrome when combined with MAOIs or other drugs that increase serotonin (tyramine). Treat with cyproheptadine.

Front 75

Venlafaxine mechanism of action?

Back 75

SNRIs; inhibits serotonin and norepinephrine reuptake.

Front 76

Venlafaxine uses?

Back 76

Depression generalized anxiety disorder.

Front 77

Venlafaxine side effects?

Back 77

Increase in blood pressure, stimulant effects, sedation, nausea.

Front 78

Duloxetine mechanism of action?

Back 78

SNRIs; inhibits serotonin and norepinephrine reuptake. Stronger NE effect than venlafaxine.

Front 79

Duloxetine uses?

Back 79

Depression, diabetic peripheral neuropathy.

Front 80

Duloxetine side effects?

Back 80

Increase in blood pressure, stimulant effects, sedation, nausea.

Front 81

Phenelzine mechanism of action?

Back 81

Non-selective monoamine oxidase (MAO) inhibitors.

Front 82

Phenelzine uses?

Back 82

Atypical depression, anxiety, hypochondriasis.

Front 83

Phenelzine side effects?

Back 83

Hypertension with tyramine ingestion (foods like wine and cheese) and beta-agonists. CNS stimulation. Contraindicate with SSRIS or meperidine.

Front 84

Tranylcypromine mechanism of action?

Back 84

Non-selective monoamine oxidase (MAO) inhibitors.

Front 85

Tranylcypromine uses?

Back 85

Atypical depression, anxiety, hypochondriasis.

Front 86

Tranylcypromine side effects?

Back 86

Hypertension with tyramine ingestion (foods like wine and cheese) and beta-agonists. CNS stimulation. Contraindicate with SSRIS or meperidine.

Front 87

Isocarboxazid mechanism of action?

Back 87

Non-selective monoamine oxidase (MAO) inhibitors.

Front 88

Isocarboxazid uses?

Back 88

Atypical depression, anxiety, hypochondriasis.

Front 89

Isocarboxazid side effects?

Back 89

Hypertension with tyramine ingestion (foods like wine and cheese) and beta-agonists. CNS stimulation. Contraindicate with SSRIS or meperidine.

Front 90

Bupropion mechanism of action?

Back 90

Increases dopamine and norepinephrine release.

Front 91

Bupropion uses?

Back 91

Smoking cessation, atypical antidepressant.

Front 92

Bupropion side effects?

Back 92

Stimulant effects (tachycardia, insomnia), headache, seizure in bulimic patients. No sexual side effects. INCREASES SEIZURE THRESHOLD.

Front 93

Mirtazapine mechanism of action?

Back 93

alpha-2 adrenergic antagonist (increases release of NE and 5-HT) and potent 5-HT2/3 antagonist.

Front 94

Mirtazapine uses?

Back 94

Atypical antidepressant.

Front 95

Mirtazapine side effects?

Back 95

Sediation, increased appetite, weight gain, dry mouth.

Front 96

Maprotiline mechanism of action?

Back 96

Inhibits norepinephrine reuptake.

Front 97

Maprotiline uses?

Back 97

Atypical antidepressant.

Front 98

Maprotiline side effects?

Back 98

Sedation, orothostation hypotension.

Front 99

Trazodone mechanism of action?

Back 99

Inhibits serotonin reputake.

Front 100

Trazodone uses?

Back 100

Atypical antidepressant; typically used for insomnia.

Front 101

Trazodone side effects?

Back 101

Priapism, postural hypotension, sediation, nausea.

Front 102

Modafinil mechanism of action?

Back 102

Stimulates orexins; increases dopamine, noradrenaline, and serotonin levels.

Front 103

Disulfiram mechanism of action?

Back 103

Acetylaldehyde dehydrogenase inhibitor; causes buildup of toxic acetylaldehyde.

Front 104

Disulfiram uses?

Back 104

Produces acute sensitivity to alcohol consumption.

Front 105

Varenicline mechanism of action?

Back 105

Nicotinic receptor partial agonist.

Front 106

Varenicline uses?

Back 106

Smoking cessation.

Front 107

Varenicline side effects?

Back 107

Increased risk of suicide, CV disease.

Front 108

Naloxone mechanism of action?

Back 108

Opioid antagonist.

Front 109

Naloxone uses?

Back 109

Emergency opioid overdose treatment; used IV.

Front 110

Naltrexone mechanism of action?

Back 110

Opioid antagonist.

Front 111

Naltrexone uses?

Back 111

Dependence treatment, used orally.

Front 112

Flumazenil mechanism of action?

Back 112

BDZ antagonist.

Front 113

Flumazenil uses?

Back 113

Benzodiazepine overdose; can't be used for barbituate or alcohol overdose.

Front 114

Cyproheptadine mechanism of action?

Back 114

5-HT2 antagonist.

Front 115

Cyproheptadine uses?

Back 115

Treats serotonin syndrome (hyperthermia, muscle rigidity, CV collapse, flushing, diarrhea, seizures) from the combination of SSRIs and other serotonin increasing drugs (MAOIs).